Adams MA

Ahmad Omair

Ala-Kokko L

Andersson GB

Barrett JC

Battie MC

Benedicte Alexandra Lie

Brox JI

Buckwalter JA

Cavanaugh JM

Chan D

Cheung KM

Cong L

Deyo RA

Doita M

Dong DM

Dudbridge F

Eyre DR

Fiszer D

Fujiwara A

Haldane JB

Heliovaara M

Jens Ivar Brox

Jensen MC

Jim JJ

Kalichman L

Kang JD

Katz JN

Kawaguchi Y

Kelsey JL

Koshizuka Y

Koskinen LL

Lee S

Loughlin J

Maroudas A

Matsui H

Miller SA

Mio F

Nakki A

Natvig B

Novembre J

Olav Reikeras

Paassilta P

Pluijm SM

Pope MH

Poulou M

Puren AJ

Rannou F

Richardson JK

Seki S

Shao XT

Solovieva S

Sun ZM

Svensson HO

Takahashi M

Valdes AM

Videman T

Wang X

Williams FM

Woolf B

Yuan HY

Zhernakova A

Open Orthopaedics Journal

English

PubMed


            Objectives:
            To examine association of candidate genetic variants in structural, inflammatory, matrix modifying, vitamin D receptor genes and variants associated with osteoarthritis, with surgical candidates and surgical patients with lumbar disc degeneration (LDD), in light of their previously reported susceptibility for LDD.
                
               
            Methods:            
 Genotyping of 146 Norwegian LDD patients and 188 Norwegian controls was performed for 20 single-nucleotide polymorphisms (SNPs) from collagen, aggrecan, interleukin, VDR, MMP3 and COX2 genes and 7 SNPs from osteoarthritic genes.
                
               
            Results:                 
                The neighboring genes IL18R1 and IL18RAP polymorphisms (rs2287037 and rs1420100), showed a statistically non-significant risk for developing LDD (OR 1.36 [95 % CI 0.99 – 1.87]; p=0.06 and OR 1.33 [95 % CI 0.98-1.81]; p=0.07). Homozygosity of these risk alleles was associated with LDD (p=0.023 and p=0.027). The non-risk alleles at these SNPs were situated on a haplotype negatively associated with LDD (p=0.008). Carriage of at least one non-risk allele at both loci also reduces the risk of developing LDD (OR 0.51 [95 % CI 0.33-0.80]; p=0.003).
                
               
            Conclusion:                  
                Our findings support the polygenic nature of LDD and suggest that variation in interleukin 18 receptor genes could affect the risk of severe LDD and associated low back pain.
            </jats:sec

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The Open Orthopaedics Journal

An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration

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An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration

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