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Anticancer peptides : prospective innovation in cancer therapy
Authors
Miguel A. R. B. Castanho
Diana Gaspar Gaspar
Publication date
1 January 2016
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
© Springer International Publishing Switzerland 2016Current cancer treatments require improvements in selectivity and efficacy. Surgery, radiation, and chemotherapy approaches result in patient’s suffering over time due to the development of severe side-effects that simultaneously condition adherence to therapy. Biologically active peptides, in particular antimicrobial peptides (AMPs), are versatile molecules in terms of biological activities. The cytotoxic activities of several AMPs turn this group of molecules into an amazing pool of new templates for anticancer drug development. However, several unmet challenges limit application of peptides in cancer therapy. The mechanism(s) of action of the peptides need better description and understanding, and innovative targets have to be discovered and explored, facilitating drug design and development. In this chapter, we explore the natural occurring AMPs as potential new anticancer peptides (ACPs) for cancer prevention and treatment. Their modes of action, selectivity to tumor compared to normal cells, preferential targets, and applications, but also their weaknesses, are described and discussed.info:eu-repo/semantics/publishedVersio
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Repositório da Universidade de Lisboa
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oai:repositorio.ul.pt:10451/32...
Last time updated on 12/06/2020
Crossref
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info:doi/10.1007%2F978-3-319-3...
Last time updated on 03/08/2021
Universidade de Lisboa: Repositório.UL
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Last time updated on 17/04/2018