Lysine Decarboxylase Catalyzes the First Step of Quinolizidine Alkaloid Biosynthesis and Coevolved with Alkaloid Production in Leguminosae[W][OA]

Abstract

Quinolizidine alkaloids (QAs) are specialized metabolites found mostly in the Leguminosae. This study identifies lysine/ornithine decarboxylases involved in the first step of QA biosynthesis, highlighting the occurrence of lysine decarboxylase in QA-producing plants with regulation and evolution of QA biosynthesis