Fantini, F

Gattinara, M

Gerloni, V

Lurati, A

Pontikaki, I

Salmaso, A

Teruzzi, B

English

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Pediatric Rheumatology
Open AccessPoster presentation
Efficacy of a second TNF blocker, when the first one failed, in 
patients with juvenile idiopathic arthritis (JIA)
A Salmaso*1, A Lurati2, I Pontikaki1, V Gerloni1, M Gattinara1, B Teruzzi1 and 
F Fantini1
Address: 1Gaetano Pini Institute Chair of Rheumatology, Milan, Italy and 2Fornaroli Hospital Rheumatology Unit, Magenta, Italy
* Corresponding author    
Objectives
To determine the efficacy of a second treatment with a dif-
ferent TNF blocker in JIA when the first one failed.
Methods
All JIA patients prospectively followed at our Centre, who
failed a first TNF blocker and switched to a second one
were enrolled. For each patient the DAS, ACR Ped30,
ACR20, ACR50 and ACR70 responses were evaluated at
baseline and after a period ranging from 3 to 6 months of
each treatment.
Results
Out of 60 JIA patients enrolled, 40 (37 f, 3 m) were eval-
uated: 10 systemic arthritis, 2 persistent oligoarthritis, 11
extended oligoarthritis, 9 RF negative polyarthritis, 4 RF
positive polyarthritis, 1 ERA (enthesitis related arthritis),
3 psoriatic arthritis. With a standard Chi square model, we
didn't find a significant difference in the ACR and DAS
response rates between the first and the second anti TNF
treatment (p > 0.1). Stratifying the population for the type
of the shift (Etanercept to Infliximab/Adalimumab, Inflix-
imab to Etanercept/Adalimumab) we didn't find a signif-
icant difference in the ACR and DAS response rates
between the first and the second anti TNF treatment (p >
0.1). Our data show that failure of an anti-TNF therapy in
patients with JIA does not preclude a response to a second
anti-TNF agent of a different class.
from 15th Paediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008
Published: 15 September 2008
Pediatric Rheumatology 2008, 6(Suppl 1):P44 doi:10.1186/1546-0096-6-S1-P44
<supplement> <title> <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> </title> <editor>Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/PDF/1546-0096-6-S1-full.pdf">here</a>.</note> </supplement>
This abstract is available from: http://www.ped-rheum.com/content/6/S1/P44
© 2008 Salmaso et al; licensee BioMed Central Ltd. 


Efficacy of a second TNF blocker, when the first one failed, in patients with juvenile idiopathic arthritis (JIA)

A Salmaso

A Lurati

I Pontikaki

V Gerloni

M Gattinara

B Teruzzi

F Fantini

Salmaso A

Lurati A

Pontikaki I

Gerloni V

Gattinara M

Teruzzi B

Fantini F

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Efficacy of a second TNF blocker, when the first one failed, in patients with juvenile idiopathic arthritis (JIA)

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