Etheridge, A

Hirani, SP

Kassoumeri, L

Mulligan, K

Newman, SP

Ruperto, N

Wedderburn, L

Woo, P

English

PubMed

SP Hirani

L Kassoumeri

A Etheridge

K Mulligan

N Ruperto

P Woo

L Wedderburn

SP Newman

null null

Springer - Publisher Connector

Investigating the use of a limited core outcome variable set for the classification of response following methotrexate treatment in juvenile idiopathic arthritis (JIA)

Hirani SP

Kassoumeri L

Etheridge A

Mulligan K

Ruperto N

Woo P

Wedderburn L

Newman SP

Directory of Open Access Journals

Pediatric Rheumatology

BioMed Central
Page 1 of 1
(page number not for citation purposes)
Pediatric Rheumatology
Open AccessPoster presentation
Investigating the use of a limited core outcome variable set for the 
classification of response following methotrexate treatment in 
juvenile idiopathic arthritis (JIA)
SP Hirani*1, L Kassoumeri2, A Etheridge2, K Mulligan1, Collaborators 
PRINTO3, N Ruperto3, P Woo4, L Wedderburn2 and SP Newman1
Address: 1UCL Behavioural Medicine, London, UK, 2UCL Institiute of Child Health, London, UK, 3Paediatric Rheumatology International Trials 
Organization, Genova, Italy and 4UCL Centre of Paediatric and Adolescent Rheumatology, London, UK
* Corresponding author    
Background
The utility of the core outcome variable (COV) classifica-
tion procedure as a method of gauging response to treat-
ment in JIA is often jeopardised by missing data. To
investigate how accurately cases are classified as respond-
ers or non-responders with a limited set of data, this study
systematically examined how the exclusion of core varia-
bles influenced classification.
Methods
From a complete dataset of 410 JIA patients (provided by
PRINTO), variables were systematically excluded and
cases reclassified as responders or non-responders accord-
ing to the criteria of improvement at 30%, 50% or 70%.
Comparisons of the sensitivity, specificity were utilised to
calculate overall accuracy of classification for each limited
dataset in comparison to classification via the full dataset.
Results
The systematic removal of one variable resulted in low-
ered accuracy of classification in the ranges of 86.5–
91.8%, 81.7–93.9% and 79.5–88.6% at the 30%, 70%
and 50% criteria levels. Exclusion of the CHAQ had the
least impact, while exclusion of the number of active
joints had the greatest impact on accuracy. As the percent-
age criteria became more stringent the overall accuracy
reduced, however even at the 70% criteria up to 89% accu-
racy was possible if only the CHAQ was omitted. The
omission of both parental global rating and the CHAQ
had a particularly large impact on sensitivity and accuracy.
Conclusion
It is possible that a limited set of variables can lead to a rel-
atively accurate indication of the response to treatment by
JIA patients, but careful consideration of the precise varia-
ble(s) omitted is required.
from 15th Paediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008
Published: 15 September 2008
Pediatric Rheumatology 2008, 6(Suppl 1):P119 doi:10.1186/1546-0096-6-S1-P119
<supplement> <title> <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> </title> <editor>Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/PDF/1546-0096-6-S1-full.pdf">here</a>.</note> </supplement>
This abstract is available from: http://www.ped-rheum.com/content/6/S1/P119
© 2008 Hirani et al; licensee BioMed Central Ltd. 


Crossref

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3333915

Investigating the use of a limited core outcome variable set for the classification of response following methotrexate treatment in juvenile idiopathic arthritis (JIA)

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Directory of Open Access Journals

Springer - Publisher Connector

Crossref