Surgery is the therapy of choice for melanoma. However, as it is non-radical, or if the histopathological examination shows presence of adverse predictive indicators, additional (adjuvant) treatment is necessary. Radiation therapy, either curative or palliative, proved to be effective. Moreover, if we follow the modern principles of the discipline and use advanced technology, it is also safe. Therefore, radiation therapy is today an indispensable part of the multidisciplinary management of melanoma patients