Christensen, IJ

Falkenström, D

Hermann, NV

Kreiborg, S

Nielsen, S

Pedersen, FK

Zak, M

English

PubMed

M Zak

D Falkenström

IJ Christensen

NV Hermann

S Nielsen

FK Pedersen

S Kreiborg

Springer - Publisher Connector

Mandibular condyle destruction in juvenile idiopathic arthritis (JIA)

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BioMed Central
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Pediatric Rheumatology
Open AccessPoster presentation
Mandibular condyle destruction in juvenile idiopathic arthritis (JIA)
M Zak*1,2, D Falkenström1, IJ Christensen1, NV Hermann1, S Nielsen1, 
FK Pedersen1 and S Kreiborg1
Address: 1State University Hospital, Rigshospitalet, Copenhagen, Denmark and 2University of Copenhagen, Copenhagen, Denmark
* Corresponding author    
Aim
Assessment of destruction of the mandibular condyle in
relation to clinical baseline data and disease progression
in JIA.
Materials and methods
293 consecutive patients (f = 198; m = 95) diagnosed
1995–2006 participated. Median JIA onset age was 6 1/2
yrs for girls and 8 yrs for boys. ILAR classification: persist-
ent-oligoarticular (p-oligo) 26%, extended-oligoarticular
(e-oligo) 24%, polyarticularRF- (poly-) 22%, polyarticu-
larRF+ (poly+) 1%, enthesitis-associated (ERA) 16%, pso-
riatic (pso) 6% and systemic (sys) 5%. Disease course,
uveitis, ANA, IgM-RF and HLA-B27 was recorded. Due to
small numbers sys, poly+ and pso were excluded from sub-
type analysis. Patients with poly- and e-oligo were regarded
as polyarticular course. Orthopantomographics was done in
all. 79% had 2 or more radiographs. Condylar morphol-
ogy grading was: 0 = normal; 1 = erosions of the surface; 2
= flattening; 3 = total destruction.
Results and discussion
At the first examination, 28% had radiographic TMJ
changes (1:29%; 2:66%; 3:5%). During the observation
period, additional 7% developed TMJ changes, increasing
the total frequency to 35%. 10 pt. with condylar lesions
showed progression during the observation period. TMJ
changes were significantly associated with ANA+. No
other baseline associations were observed. In logistic
regression models for TMJ changes, the following inde-
pendent variables contributed significantly to the equa-
tion: ANA+ (p = 0.01), ILAR subtype (p = 0.009), and age
(p = 0.02) at first examination. The OR for polyarticular
course vs. ERA was 4.6 (95%CI:1.7–12.5) and p-oligo vs.
ERA 2.9 (95%CI:1.0–8.0).
Conclusion
A lower frequency of mandibular condyle destruction in
JIA than reported in several previous studies was found.
Progression of changes was mild to moderate. The data
suggest that condyle destruction in JIA is associated with
ILAR subtype, age at disease onset and ANA+.
from 15th Paediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008
Published: 15 September 2008
Pediatric Rheumatology 2008, 6(Suppl 1):P43 doi:10.1186/1546-0096-6-S1-P43
<supplement> <title> <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> </title> <editor>Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/PDF/1546-0096-6-S1-full.pdf">here</a>.</note> </supplement>
This abstract is available from: http://www.ped-rheum.com/content/6/S1/P43
© 2008 Zak et al; licensee BioMed Central Ltd. 


Mandibular condyle destruction in juvenile idiopathic arthritis (JIA)

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