al., et

Ellis, Matthew J.

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Supplementary AppendixThis appendix has been provided by the authors to give readers additional information about their work.Supplement to: Sparano JA, Gray RJ, Ravdin PM, et al. Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer. N Engl J Med 2019;380:2395-405. DOI: 10.1056/NEJMoa1904819 2  Supplement to: Sparano JA, Gray RJ, Ravdin, PM, et al. Integrating clinical and genomic risk in breast cancer to guide adjuvant therapy. Table of Contents  1. List of contributors............................................................................................................ 3-9 2. Figure S1. Nine-year DRFI rates by age and chemotherapy treatment in women with a recurrence score 16 to 25 using a natural spline model with 3 degrees of freedom.          .............................................................................................................................................. 10       3 1. Contributors Institution Name Principal Investigator Abbott Northwestern Hospital Patrick Flynn Advocate Lutheran General Hospital                 Sigrun Hallmeyer  Albert Einstein College of Medicine Joseph Sparano Allan Blair Cancer Centre Muhammad Salim Allegheny General Hospital                         Thomas Julian  Augusta University Medical Center Sharad Ghamande Australian New Zealand Breast CTG                  Janine Lombard Baptist Health Cancer Research Network             Elvis Donaldson  Baptist Health Lexington                          Lee G. Hicks                           Bay Area Tumor Institute James Feusner Baylor College of Medicine                         Mothaffar Rimawi  BCCA-Cancer Centre for the Southern Interior       Barbara Czerkawski                                 BCCA-Fraser Valley Cancer Centre                   Lee Ann Martin                                     BCCA-Vancouver Cancer Centre                       Stephen Chia                                       BCCA-Vancouver Island Cancer Centre                Vanessa Bernstein                                  Berkshire Hematology Oncology PC                   Harvey Zimbler Beth Israel Deaconess Medical Center               Michael Atkins                 Brooke Army Medical Center  Lindsey J. Graham                    Cancer Alliance of Nebraska                        Gamini Soori                                       Cancer Care Specialists of Central Illinois James Wade                                         Cancer Center of Kansas Shaker Dakhil Cancer Center of Santa Barbara                     Frederick Kass Cancer Trials Ireland                              Sean McDermott                 CancerCare Manitoba                                Lorne Brandes                                      Capital Region Radiation Oncology Center                James L. Wade, III                                Carle Cancer Center Kendrith Rowland Carolinas Medical Center/Levine Cancer Institute   Antoinette Tan  Case Western Reserve University Bruce Averbook Case Western Reserve University                    Edward Mansour Case Western Reserve University                    Steven Waggoner Cedar Rapids Oncology Associates Martin Wiesenfeld Christiana Care Health System-Christiana Hospital  Stephen Grubbs CHUM-Hotel Dieu du Montreal                        Andre Robidoux  City of Hope Comprehensive Cancer Center  Joanne E.  Mortimer           Cleveland Clinic Foundation Robert Dreicer Coborn Cancer Center at Saint Cloud Hospital Donald Jurgens Columbia Saint Mary's Water Tower Medical Commons  Craig Schulz  Columbia University Medical Center Daniel Petrylak Covenant Medical Center-Lakeside                   Ibrahim Shalaby  CoxHealth South Hospital                       J. Wendall Goodwin CoxHealth South Hospital                        Robert L. Carolla                             4 Credit Valley Hospital                             Robert Myers  Creighton University Medical Center  James A. Mailliard  CSSS Champlain-Charles Le Moyne                    Catherine Prady Dana-Farber / Partners CancerCare  Harold Burstein Dana-Farber/Harvard Cancer Center                  Ursula Matulonis Dartmouth College - Norris Cotton Cancer Center Konstantin Dragnev Dartmouth Hitchcock Medical Center                 Lesley Jarvis  Dartmouth Hitchcock Medical Center                 Mary Chamberlin Dayton Physicians LLC-Samaritan North Howard Gross Desert Regional Medical Center                     Elber Camacho Doctor's Hospital of Laredo Eduardo Miranda Duke University - Duke Cancer Institute Jeffrey Crawford Eastern Maine Medical Center                       Sheila Pascual Eastern Maine Medical Center Cancer Care Thomas Openshaw Edward Hospital/Cancer Center                      Alexander Hantel  Edwards Comprehensive Cancer Center Maria Tria Tirona Emory University/Winship Cancer Institute          Charles Staley                 Emory University/Winship Cancer Institute          William Wood                   Essentia Health Cancer Center  Daniel Nikcevich Florida Cancer Specialists - Sarasota Downtown     Fadi Kayali  Fox Chase Cancer Center                            Lori Goldstein                 Froedtert and the Medical College of Wisconsin Tina Yen Froedtert and the Medical College of Wisconsin     Elizabeth Gore  Froedtert and the Medical College of Wisconsin     Paul S. Ritch Geisinger Wyoming Valley/Henry Cancer Center Srilatha Hosur Georgia Regents University Anand Jillella Glens Falls Hospital                               Robert Sponzo Good Samaritan Hospital - Cincinnati Kevin Grannan Greenville Health System Cancer Institute-Eastside Jeffrey K.Giguere Grupo de Estudios Clinicos Oncologicos del Peru    Carlos Vallejos Sologuren                            Halifax Health Medical Center-Cente                Herbert Keman Hartford Hospital                                  Patricia DeFusco  Health Sciences North                              Pedro Lopez Hematology Oncology Associates of Central New York Jeffrey Kirshner Henry Ford Hospital                          Robert A. Chapman        Hopital Maisonneuve-Rosemont                       Pierre Dube     Horizon Health Network-Saint John Regional Hospital    Margot Burnell    Huntsman Cancer Institute/University of Utah John H. Ward                                     Illinois Oncology Research Associates John Kugler Indiana Univ/Melvin and Bren Simon Cancer Center   Patrick Loehrer                Intermountain Medical Center Craig Nichols Iowa Oncology Research Associates Robert Behrens Iowa Oncology Research Associates Roscoe Morton JHU Sidney Kimmel Comprehensive Cancer Center Lisa Jacobs  5 John H Stroger Hospital of Cook County Howard Zaren John H Stroger Hospital of Cook County Thomas Lad John Muir Medical Center-Concord Campus         Robert L. Robles Johns Hopkins University/Sidney Kimmel Cancer Center     Arlene Forastiere              Johns Hopkins University/Sidney Kimmel Cancer Center     Deborah Armstrong  Kaiser Permanente                Louis Fehrenbacher    Kansas Institute of Medicine Cancer and Blood Center Rakesh Gaur Lankenau Hospital Paul Gilman Laura and Issac Perlmutter Cancer Center at NYU Langone   Deirdre Cohen                  Laura and Issac Perlmutter Cancer Center at NYU Langone   Howard Hochster                Le centre hosp affilie univ de Quebec-St Sacrement    Christine Desbiens     Louisiana State University Health Sciences Center Glen M. Mills Lousiana State University Medical Center Jill Gilbert Lousiana State University Medical Center Rajasekharan (Raj) Warrier Lousiana State University Medical Center Robert Veith Loyola University Medical Center              Patrick J. Stiff       Lynn Regional Cancer Center             Charles Vogel M D Anderson Cancer Center Scott M. Lippman M D Anderson Cancer Center                         Jack Phan M D Anderson Cancer Center                         Roy S. Herbst Marin General Hospital                            Peter D. Eisenberg Marshfield Clinic Matthias Weiss Marshfield Clinic Tarit Kumar Banerjee Massachusetts General Hospital Donald Lawrence Mayo Clinic  Kurt Jaeckle Mayo Clinic                                        Gretchen Glaser  Mayo Clinic                                        Thomas Habermann               McGill University Department of Oncology           Wilson Miller                                      Medical University of South Carolina Robert K. Stuart                                           MedStar Franklin Square Medical Center Edward McCarron  MedStar Georgetown University Hospital Sonia Reichert  Meharry Medical College Steven Wolff Memorial Hospital of South Bend Bilal Ansari Memorial Hospital of South Bend Jose Bufill Memorial Hospital of South Bend Rafat Ansari Memorial Sloan-Kettering Cancer Center Michael Morris Mercy Cancer Center                                Sonia Reichert  Mercy Clinic Cancer and Hematology Jay Carlson Metairie Oncologists LLC                           Jayne Gurtler Michigan State University Clinical Center          DeimanteTamkus  Missouri Baptist Medical Center Bryan A. Faller Moffitt Cancer Center                              Hugo Fernandez Montefiore Medical Center Peter Wiernik Mount Sinai Hospital Lewis Silverman  6 Mount Sinai Medical Center Michael Schwartz MultiCare Gig Harbor Medical Park John Keech Natalie Warren Bryant Cancer Center at Saint Francis  James Lockhart Nevada Cancer Research Foundation John Ellerton New Hampshire Oncology Hematology PA-Hooksett Douglas Weckstein Newark Beth Israel Medical Center                  Lori Schleicher  Northeast Georgia Medical Center-Gainesville Kendal Dixon Northeast Radiation Oncology Center                Christopher Peters  NorthShore University HealthSystem-Evanston Hospital  David Grinblatt NorthShore University HealthSystem-Evanston Hospital  Gershon Locker Northside Hospital Guilherme H.C. Cantuaria                         Northwell Health/Center for Advanced Medicine Daniel Budman Northwell Health/Center for Advanced Medicine    Lora Weiselberg  Northwestern University                            Al Benson                      Northwestern University                            Eric Donnelly  Ochsner Clinic Carl Kardinal Ochsner Clinic Jyotsna Fuloria Odette Cancer Center - Sunnybrook Health Sciences Center  Rebecca Dent Ohio State University Comprehensive Cancer Center Claire Verschraegen Oncology Hematology Care Inc-Blue Ash              Patrick Ward Oregon Health and Science University  Christopher W. Ryan                                            Palo Verde Cancer Specialists Lawrence Kasper Penn State Milton S Hershey Medical Center         Witold Rybka                   Penticton Regional Hospital                        Deepu Mirchandani                                  Presbyterian - Saint Lukes Medical Center - Health One  Eduardo Pajon Princeton Community Hospital Rowena Gonzales-Chambers Providence Hospital                      Anibal Drelichman             Providence Hospital                                Michael Meshad Providence Saint Vincent Medical Center Alison Conlin Rhode Island Hospital Howard Safran Riverside Methodist Hospital  John Kuebler Rocky Mountain Oncology Benjamin T. Marchello                     Roswell Park Cancer Institute Ellis Levine Rutgers Cancer Institute of New Jersey             Deborah Toppmeyer  Rutgers Cancer Institute of New Jersey             Joseph Aisner                  Rutgers New Jersey Medical School Robert Wieder Saint Joseph Hospital - Orange                     Lawrence Wagman  Saint Joseph Mercy Hospital  Philip Stella Saint Louis University Hospital               Paul J. Petruska       Saint Michael's Hospital                           Rashida Haq                                        Saint Vincent Hospital Cancer Center Anthony Jaslowski Saint Vincent Hospital Cancer Center Green Bay                                 Gerald Kurt Bayer                             San Juan City Hospital Luis Baez-Diaz Sanford Cancer Center Oncology Clinic Loren Tschetter  7 Sanford Cancer Center Oncology Clinic Maria Bell Sanford Cancer Center Oncology Clinic Miroslaw Mazurczak Sanford Medical Center-Fargo Preston Steen Saskatoon Cancer Centre                            Shahid Ahmed                                       Scott & White Memorial Hospital Lucas Wong Sharp Memorial Hospital Robert Barone Sky Ridge Medical Center Keren Sturtz Southeastern Medical Oncology Center James Atkins Southwestern Vermont Medical Center                Matthew Vernon  Spectrum Health at Butterworth Campus Kathleen Yost Spectrum Health at Butterworth Campus Marianne K. Melnik   Stanford Cancer Institute Palo Alto                Harlan Pinto                   Stanford Cancer Institute Palo Alto                Sandra Horning                 Stanford University                                Beth Beadle State University of New York Upstate Medical University Stephen Graziano Staten Island University Hospital                  Terenig Terjanian  Stony Brook University Medical Center              Michael Pearl  Sutter Cancer Research Consortium                  Christopher Jones  Swedish Medical Center-First Hill Saul E. Rivkin The Community Hospital                             Mohamad Kassar  The Moncton Hospital                               Hazem Assi                                         Thomas Jefferson University Hospital               Maria Werner-Wasik  Thompson Cancer Survival Center               S. Spence McCachren                              Thompson Cancer Survival Center                    Zhang Wenqing Thunder Bay Regional Health Science Centre         Adrien Chan                                        Toledo Clinic Cancer Centers-Toledo Rex Mowat Toledo Clinic Cancer Centers-Toledo                Paul L. Schaefer                       Tom Baker Cancer Centre                            Marc Webster                                       Toronto East General Hospital                      Yasmin Rahim                                       Trillium Health Centre-West Toronto                John Gapski                                        Trinity Cancer Care Center                         Stephen Makoni Tufts Medical Center Frank Haluska Tufts Medical Center John Erban Tufts Medical Center Richard Van Etten Tulane University Health Sciences Center     Hana F. Safah   Tulane University Health Sciences Center            William Robinson UC Irvine Health/Chao Family Comprehensive Cancer Center  Krishnansu Tewari  UC Irvine Health/Chao Family Comprehensive Cancer Center  Sai-Hong Ignatius Ou UC San Diego Moores Cancer Center Barbara Parker UC San Diego Moores Cancer Center                  Loren Mell  UCLA / Jonsson Comprehensive Cancer Center  John A. Glaspy    UCLA / Jonsson Comprehensive Cancer Center         Robin Farias-Eisner  UCSF Medical Center-Mount Zion Charalambos Andreadis UCSF Medical Center-Mount Zion                     Mack Roach   8 UF Cancer Center at Orlando Health                 Eleftherios (Terry) Mamounas  UNC Lineberger Comprehensive Cancer Center Thomas E. Seay UNC Lineberger Comprehensive Cancer Center Thomas Shea University of Alabama at Birmingham Cancer Center  Carla Falkson                  University of Arizona Medical Center-University Campus Thomas P. Miller                            University of Arkansas for Medical Sciences Laura Hutchins       University of California Davis Comp Cancer Center  David R. Gandara                                       University of Chicago Comprehensive Cancer Center Mitchell Posner University of Cincinnati                           Eric Eisenhauer  University of Cincinnati                           Leslie Oleksowicz                   University of Cincinnati                           Rami S. Komrokji                         University of Cincinnati                            Zeina A. Nahleh University of Colorado Cancer Center Rachel Rabinovitch University of Colorado Cancer Center  Anthony D.  Elias  University of Connecticut                          Eric Eisenhauer  University of Hawaii Cancer Center Jeffrey Berenberg University of Illinois at Chicago David Peace University of Illinois at Chicago John Quigley University of Illinois at Chicago  Lawrence Feldman University of Iowa/Holden Comprehensive Cancer Center David Bender  University of Iowa/Holden Comprehensive Cancer Center Laith Abushahin University of Kansas Medical Center     Karen Kelly University of Kentucky/Markey Cancer Center        David Bender  University of Maryland/Greenebaum Cancer Center Heather Mannuel University of Maryland/Greenebaum Cancer Center    Mark Mishra  University of Massachusetts Medical School William Walsh University of Miami Caio Max Rocha Lima            University of Michigan Comprehensive Cancer Center Laurence H. Baker,  University of Minnesota/Masonic Cancer Center Bruce Peterson University of Mississippi Medical Center R. Darryl Hamilton University of Missouri - Ellis Fischel Puja Nistala University of Nebraska Medical Center Julie Vose University of New Mexico Fa-Chyi Lee University of North Carolina at Chapel Hill        Simon Khagi  University of Oklahoma Health Sciences Center Adam Asch University of Pennsylvania/Abramson Cancer Center  Daniel Haller                  University of Pennsylvania/Abramson Cancer Center  Robert Burger  University of Pittsburgh Cancer Institute Warren Robinson  University of Pittsburgh Cancer Institute   John Kirkwood                  University of Rochester                          Jonathan W. Friedberg University of Rochester                            Yuhchyau Chen  University of South Alabama Thaddeus A. Beeker      University of Southern California Heinz-Josef Lenz                               University of Tennessee Health Science Center  Ari M. VanderWalde  9 University of Texas Medical Branch Ian M. Thompson                                University of Vermont College of Medicine          Christopher Anker  University of Wisconsin Hospital and Clinics       Brad Kahl                      University of Wisconsin Hospital and Clinics       James Stewart                  Vanderbilt University/Ingram Cancer Center         David Johnson                  Vanderbilt University/Ingram Cancer Center         Jordan Berlin                  Virginia Oncology Associates-Hampton               John Paschold  Wake Forest University Health Sciences William Petty Walter Reed National Military Medical Center Michelle Ojemuyiwa Washington University - Siteman Cancer Center Nancy Bartlett Washington University School of Medicine           David Mutch Wayne State University/Karmanos Cancer Institute Lawrence Flaherty Wayne State University/Karmanos Cancer Institute   Michael Dominello Weill Medical College of Cornell University Manish Shah WellSpan Health-York Hospital                      Amit Shah  West Michigan Cancer Center Raymond Lord West Virginia University Healthcare                Mohamad Salkeni  Wilford Hall Medical Center                            Bradley A. McGregor                     Wilford Hall Medical Center                            Douglas A. Nelson                    Wilford Hall Medical Center                            John S. Renshaw Wilford Hall Medical Center                            Michell A. Garrison                   Wilford Hall Medical Center                            Thomas J. Richard               William Beaumont Hospital John M. Robertson        Windsor Regional Cancer Centre                     Caroline Hamm                                      Yale University                                    Roy Decker   10 Figure S1.  Nine-year DRFI rates by age and chemotherapy treatment in women with a recurrence score 16 to 25 using a natural spline model with 3 degrees of freedom.          

Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer

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Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer

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