Transient electronics entails the capability of electronic components to dissolve or reabsorb in a controlled manner when used in biomedical implants. Here, the authors perform a systematic study of the processes of hydrolysis, bioabsorption, cytotoxicity and immunological biocompatibility of monolayer MoS2

Ahn, Jong-Hyun

Chen, Xiang

Jeon, Seunghyun

Kang, Minpyo

Kang, Seung-Kyun

Koo, Jahyun

Lee, Kyung-Mi

MacEwan, Matthew R.

Park, Gayoung

Park, Yong Ju

Ray, Wilson Z.

Rogers, John A.

Shin, Jiho

Shinde, Sachin M.

Yan, Ying

Nature Communications

English

AbstractTransient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS2, including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models. The results show that MoS2 undergoes hydrolysis slowly in aqueous solutions without adverse biological effects. We also present a class of MoS2-based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models. Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Our findings support the broader use of 2D materials in transient electronics and qualitatively expand the design options in other areas.</jats:p

Xiang Chen

Yong Ju Park

Minpyo Kang

Seung-Kyun Kang

Jahyun Koo

Sachin M. Shinde

Jiho Shin

Seunghyun Jeon

Gayoung Park

Ying Yan

Matthew R. MacEwan

Wilson Z. Ray

Kyung-Mi Lee

John A Rogers

Jong-Hyun Ahn

Crossref

CVD-grown monolayer MoS2 in bioabsorbable electronics and biosensors

Digital Commons@Becker

Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS2, including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models. The results show that MoS2 undergoes hydrolysis slowly in aqueous solutions without adverse biological effects. We also present a class of MoS2-based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models. Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Our findings support the broader use of 2D materials in transient electronics and qualitatively expand the design options in other areas.

KAIST Institutional Repository

https://koasas.kaist.ac.kr/bitstream/10203/242249/1/000431008400006.pdf

CVD-grown monolayer MoS2 in bioabsorbable electronics and biosensors

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Digital Commons@Becker

KAIST Institutional Repository