CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
The effect of sodium fluorescein angiography on erythrocyte properties
Authors
J. Martins e Silva
C. Saldanha
+3 more
L. Sargento
P. Souza-Ramalho
L. Zabala
Publication date
1 January 1998
Publisher
'IOS Press'
Abstract
© 1998 – IOS Press. All rights reservedSodium fluorescein angiography is a widely used routine ophthalmological diagnostic procedure which enables the study of chorioretinal microcirculation and consists of the injection of sodium fluorescein into the systemic bloodstream. The aim of the present study was to evaluate whether or not fluorescein interferes with erythrocyte properties during the angiographic procedure. In a group of 37 patients, 26 with non-insulin-dependent diabetes mellitus (DM) with and without retinopathy, and 11 without diabetes mellitus (non-DM) although affected by other ophthalmological diseases, all undergoing routine angiography, blood samples were drawn before (T0) and 30 min (T30) after fluorescein injection. The erythrocyte aggregation index (EAI), membrane lipid fluidity and erythrocyte acetylcholinesterase activity were determined in both groups. After fluorescein injection there was no statistical change in EAI and erythrocyte membrane fluidity in either group. Erythrocyte acetylcholinesterase activity, a marker of membrane protein integrity, decreased significantly (p < 0:01) in the DM group. Membrane lipid fluidity did not change with fluorescein injection, however, (i) in the DM group erythrocyte membranes became more rigid than in the non-DM (DPH: p < 0:01); (ii) EAI and membrane lipid fluidity became significantly correlated (r = 0:6263, p < 0:05) in non-DM patients at T30. In conclusion, fluorescein administration for angiographic procedures seems to interact with erythrocyte membrane, namely, in diabetic patients, which may interfere with the blood flow in the microcirculation
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Repositório da Universidade de Lisboa
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:repositorio.ul.pt:10451/17...
Last time updated on 12/06/2020
Universidade de Lisboa: Repositório.UL
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:repositorio.ul.pt:10451/17...
Last time updated on 05/05/2016