The fulfillment of Koch’s postulates shows that the virus causes proventricular dilatation disease in parrots

Briese, Thomas

Gray, Patricia

Honkavuori, Kirsi S.

Hoppes, Sharman

Mirhosseini, Negin

Payne, Susan

Reddy, Sanjay M.

Shivaprasad, H.L

Suchodolski, Paulette

Tizard, Ian

Villanueva, Itamar

Emerging Infectious Diseases

English

PubMed

Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). We successfully isolated and characterized ABV from the brains of 8 birds with confirmed PDD. One isolate was passed 6 times in duck embryo fibroblasts, and the infected cells were then injected intramuscularly into 2 healthy Patagonian conures (Cyanoliseus patagonis). Clinical PDD developed in both birds by 66 days postinfection. PDD was confirmed by necropsy and histopathologic examination. Reverse transcriptionâ€“PCR showed that the inoculated ABV was in the brains of the 2 infected birds. A control bird that received uninfected tissue culture cells remained healthy until it was euthanized at 77 days. Necropsy and histopathologic examinations showed no abnormalities; PCR did not indicate ABV in its brain tissues

Shivaprasad, H. L.

Columbia University Academic Commons

Use of avian bornavirus isolates to induce proventricular dilatation disease in conures

Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). We successfully isolated and characterized ABV from the brains of 8 birds with confirmed PDD. One isolate was passed 6 times in duck embryo fibroblasts, and the infected cells were then injected intramuscularly into 2 healthy Patagonian conures (Cyanoliseus patagonis). Clinical PDD developed in both birds by 66 days postinfection. PDD was confirmed by necropsy and histopathologic examination. Reverse transcription–PCR showed that the inoculated ABV was in the brains of the 2 infected birds. A control bird that received uninfected tissue culture cells remained healthy until it was euthanized at 77 days. Necropsy and histopathologic examinations showed no abnormalities; PCR did not indicate ABV in its brain tissues

Patricia Gray

Sharman Hoppes

Paulette Suchodolski

Negin Mirhosseini

Susan Payne

Itamar Villanueva

H.L Shivaprasad

Kirsi S. Honkavuori

Thomas Briese

Sanjay M. Reddy

Ian Tizard

Directory of Open Access Journals

Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures

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Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures

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