Non-B HIV-1 was consistent with patients’ area of origin

Adrien

Bertine S. Akouamba

Bikandou

Bluma G. Brenner

Boni

Brodine

Clarke

Cuevas

Delwart

Eshleman

Fransen

Gaschen

Hugo Soudeyns

Hugues Charest

Janique Viel

Jayaraman

Johanne Samson

Kimura

Kumar

Leitner

Marc Boucher

McCutchan

Montavon

Natacha Merindol

Normand Lapointe

P. Richard Harrigan

Peeters

Perrin

Richard Lalonde

Simon

Spira

Sullivan

Thompson

Thomson

Vallet

Weidle

Emerging Infectious Diseases

English

PubMed

Crossref

HIV-1 Genetic Diversity in Antenatal Cohort, Canada

We studied HIV genetic diversity in a cohort of 127 pregnant, HIV-infected women who received prenatal care at Sainte-Justine Hospital in Montreal, Canada, between 1999 and 2003. Clade assignments were derived by phylogenetic analysis of amplified pol sequences. Genotyping was successful in 103 of 127 women, 59 (57.3%) of whom were infected with clade B HIV-1, and 44 (42.7%) with nonclade B viruses, including subtypes A, C, D, F, G, and H. Four sequences remained unassigned. Forty-three of 44 women infected with non-clade B viruses were newcomers from sub-Saharan Africa, and subtype identity was consistent with those circulating in their countries of origin. These results highlight the epidemiologic importance of non-B HIV-1 in antenatal populations in a large North American urban center, underscore the influence of population movements on clade intermixing, and identify a group of patients who could be targeted for surveillance and drug therapy followup

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HIV-1 Genetic Diversity in Antenatal Cohort, Canada

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