Heritable genetic or epigenetic changes in cells are thought to drive tumor development, metastasis, and drug resistance. This essay discusses the possibility that nonheritable phenotypic variability contributes to the evolution of cancer, suggesting new approaches to treatment

A Roesch

A Sigal

B. A Larder

C Wiuff

C. D Schlichting

C. H Waddington

D Hanahan

D. K Singh

E Frei 3rd

E Kussell

G. M Suel

H Rubin

H. H Chang

J Chmielecki

J. H Holland

J. L Fierst

J. M Baldwin

K Kaneko

K Lewis

K. M Murphy

L. W Ancel

M Greaves

M Niepel

M Pigliucci

M. J Bissell

M. J West-Eberhard

M. M Zdanowicz

Marsha Rich Rosner

N. L Komarova

P. B Gupta

P. C Nowell

R Lande

R Losick

R Yang

S Bonhoeffer

S Huang

S. A Frank

S. F Levy

S. J Altschuler

S. L Spencer

S. V Sharma

Steven A. Frank

T. D Price

English

PubMed

Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy

Steven A Frank

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PLoS Biology

Nonheritable cellular variability accelerates the evolutionary processes of cancer.

Frank, Steven A

Rosner, Marsha Rich

eScholarship - University of California

Nonheritable Cellular Variability Accelerates the Evolutionary Processes of Cancer

Crossref

Frank Steven A.

Rosner Marsha Rich

Public Library of Science (PLOS)

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Nonheritable Cellular Variability Accelerates the Evolutionary Processes of Cancer

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Crossref

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