Alexander Turin

Bryce Merritt

HY Sabet

James Carr

Jennifer A Febbo

Michael Markl

P Ou

SC Siu

Journal of Cardiovascular Magnetic Resonance

English

PubMed

Springer - Publisher Connector

Correlation between bicuspid aortic valve fusion phenotype and aortic arch morphology using MRI

POSTER PRESENTATION Open Access
Correlation between bicuspid aortic valve fusion
phenotype and aortic arch morphology using
MRI
Alexander Turin*, Bryce Merritt, Jennifer A Febbo, Michael Markl, James Carr
From 15th Annual SCMR Scientific Sessions
Orlando, FL, USA. 2-5 February 2012
Summary
The purpose of this study is to use magnetic resonance
angiography (MRA) to evaluate the relationship between
different patterns of bicuspid aortic valve (BAV) fusion
and aortic arch morphologies, as characterized by the
carotid-subclavian artery (CSA) index - of the aortic dia-
meter at the left subclavian artery to the distance
between the left carotid artery and the left subclavian
artery - and aortic arch height and width dimensions.
Background
BAV is associated with aortic aneurysms, various aortic
root morphologies, and morphological changes in the
transverse arch [1]. Although height and width para-
meters have been used to classify different shapes of the
thoracic aorta, the effects of BAV on these dimensions
have not been characterized [2]. Moreover, there has
been little investigation of the individual BAV fusion
phenotypes with the associated complications of BAV
[3]. A greater understanding of the association between
BAV fusion types and disease will help to shed light on
the nature of the hemodynamic effects of the inherent
mechanism involved.
Methods
A total of 191 patients with previously diagnosed BAV
and 26 age- and sex-matched controls with tricuspid
aortic valves (TAV) who had undergone MRA of the
chest were retrospectively identified. Measurements of
the carotid-subclavian artery index as well as the height
and width of the aortic arch were taken and compared
to BAV fusion phenotypes.
Results
The CSA index values did not differ significantly across
BAV fusion patterns, although there was significant var-
iation in the mean diameter of the aortic arch at the left
subclavian artery among all groups and an increased
carotid-subclavian artery distance in patients with left-
non (L-N) coronary cusp fusion. All BAV fusion types
are also associated with an increase in aortic arch
height. Lastly, patients with L-N fusion were also shown
to have a significantly increased aortic arch height-width
ratio (0.79 vs. 0.58, p = 0.002) compared to control.
Conclusions
Bicuspid aortic valve fusion phenotypes have an influ-
ence on aortic arch morphology, and the differences in
the aortic arch measurements both within and among
groups suggest that a hemodynamic factor is present in
aortas with BAV.
Funding
None.
Published: 1 February 2012
References
1. Siu SC, Silversides CK: J Am Coll Cardiol. 2010, 55:2789-2800.
2. Ou P, et al: Eur Heart J. 2004, 25:1853-1859.
3. Sabet HY, et al: Mayo Clin Proc. 1999, 74:14-26.
doi:10.1186/1532-429X-14-S1-P91
Cite this article as: Turin et al.: Correlation between bicuspid aortic
valve fusion phenotype and aortic arch morphology using MRI. Journal
of Cardiovascular Magnetic Resonance 2012 14(Suppl 1):P91.
Northwestern University, Chicago, IL, USA
Turin et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P91
http://www.jcmr-online.com/content/14/S1/P91
© 2012 Turin et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


Crossref

Cite this article as: Turin et al.: Correlation between bicuspid aortic valve fusion phenotype and aortic arch morphology using MRI.

Silversides CK: J Am Coll Cardiol.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3305779

Correlation between bicuspid aortic valve fusion phenotype and aortic arch morphology using MRI

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