Cao, Jie J

Holtzman, Dvorah

Kadiyala, Madhavi

McLaughlin, Jeannette

Rhee, Peter D

Journal of Cardiovascular Magnetic Resonance

English

PubMed

Dvorah Holtzman

Jeannette McLaughlin

Madhavi Kadiyala

Peter D Rhee

Jie J Cao

Crossref

Validating feature tracking MRI for the assessment of strain rate in patients with various hemodyanamic states

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ORAL PRESENTATION Open Access
Validating feature tracking MRI for the
assessment of strain rate in patients with various
hemodyanamic states
Dvorah Holtzman*, Jeannette McLaughlin, Madhavi Kadiyala, Peter D Rhee, Jie J Cao
From 15th Annual SCMR Scientific Sessions
Orlando, FL, USA. 2-5 February 2012
Background
Myocardial strain rate (SR) is a valuable measurement in
assessing myocardial mechanical properties, which can
be compared between subjects in the setting of various
hemodynamic states. Feature tracking (FT) is a novel
method to assess SR off-line on cine images acquired in
routine cardiac MRI. In this study we sought to assess
SR using the FT method in a group of patients and to
validate the relation of SR to LV ejection fraction
(LVEF) and left ventricular end diastolic pressure
(LVEDP) measured during cardiac catheterization.
Methods
Fifty two patients undergoing cardiac catheterization
and same day research cardiac MRI were prospectively
recruited. SR was analyzed in endocardial cine images of
the short axis in the mid left ventricle using FT-MRI
(Diogenes TomTec Imaging Systems). Average systolic
circumferential SR and radial SR were determined. FT
strain parameters were compared to the LV ejection
fraction (LVEF), LV end systolic (LVESV) and end dia-
stolic volume (LVEDV), and LVEDP obtained during
cardiac catheterization.
Results
Mean age of the cohort was 59 years with 32 patients
being male (61%). The average LVEF was 49±15%,
LVEDV 90±38 mL/m2 and LVEDP 14±7 mmHg. The
average circumferential SR was higher in patients with a
normal LVEF (≥50%) -1.6±0.4s-1 versus patients with a
low LVEF (<50%) -0.7±0.4s-1 (p<0.001). Significant dif-
ferences were also noted in average radial SR in patients
with normal LVEF 2.1±0.8s-1 versus 0.9±0.5</s-1
(p<0.001) in patients with a low LVEF. While average
strain rates were consistently higher in patients with a
normal LVEF, there is a lack of linear correlation
between circumferential SR and radial SR with LVEF
(p=0.241 and 0.987, respectively). In contrast, among
patients with low LVEF, the correlation was excellent
with r=0.810 (p<0.001) for circumferential SR and
r=0.730 (p=0.002) for radial SR. In univariate analysis
LVEDP significantly correlated with circumferential SR
and radial SR (r=0.579, p<0.001 and r=-0.438, p=0.001,
respectively). However, in a multivariate regression
model including LVEDP, LVEF, LVEDV, and LVESV as
covariables to assess their relationship to circumferential
SR and radial SR, LVEDP was not significantly asso-
ciated with either SR measurements while LVESV and
LVEF were significantly associated with circumferential
SR and radial SR.
Conclusions
FT-MRI is a promising method to assess SR in off-line
standard cine images. SR assessed by FT is sensitive to
change in global LV dysfunction yet independent of LV
preload condition.
Funding
None.
Published: 1 February 2012
doi:10.1186/1532-429X-14-S1-O38
Cite this article as: Holtzman et al.: Validating feature tracking MRI for
the assessment of strain rate in patients with various hemodyanamic
states. Journal of Cardiovascular Magnetic Resonance 2012 14(Suppl 1):O38.
St. Francis Hospital Roslyn, Long Island, Greenvale, NY, USA
Holtzman et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):O38
http://www.jcmr-online.com/content/14/S1/O38
© 2012 Holtzman et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.


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Validating feature tracking MRI for the assessment of strain rate in patients with various hemodyanamic states

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