Barac, Ana

Fuisz, Anthon

Gonzalez, Manuel A

Kern, Michael

Torguson, Rebecca

Waksman, Ron

Weissman, Gaby

English

PubMed

Gaby Weissman

Michael Kern

Ana Barac

Manuel A Gonzalez

Rebecca Torguson

Ron Waksman

Anthon Fuisz

Springer - Publisher Connector

cMR in acute myocardial infarction: correlation between myocardial scar and echocardiographic strain

Weissman Gaby

Kern Michael

Barac Ana

Gonzalez Manuel A

Torguson Rebecca

Waksman Ron

Fuisz Anthon

Directory of Open Access Journals

Journal of Cardiovascular Magnetic Resonance

POSTER PRESENTATION Open Access
cMR in acute myocardial infarction: correlation
between myocardial scar and echocardiographic
strain
Gaby Weissman1*, Michael Kern2, Ana Barac1, Manuel A Gonzalez1, Rebecca Torguson1, Ron Waksman1,
Anthon Fuisz1
From 15th Annual SCMR Scientific Sessions
Orlando, FL, USA. 2-5 February 2012
Summary
Global longitudinal and circumferential strain was
assessed by echo in 15 patients after acute MI. MRI
parameters including ventricular volumes, scar, and area
at risk were assessed 3+/-2 days post STEMI and at 30
day follow up. Echo strain measures correlated most
strongly with LVEF (r=0.81 and 0.88 longitudinal ad cir-
cumferential strain, p<0.0001) and infarct size (r=-0.68
and r=-0.69, p<0.001). There were moderate correlations
between longitudinal strain and change in LVEDV (r=-
0.61, p<0.05).
Background
Cardiac MR (CMR) is a powerful tool in the evaluation
myocardial scar and volumes. Speckle tracking by echo
is used to evaluate myocardial strain. The correlation
between strain measures and MR measures of scar is
not well defined.
Hypothesis
CMR parameters, area at risk (AAR), infarct size (IS),
and salvage area (SA), correlate with global echo strain
in patients with a ST elevation MI (STEMI).
Methods
Contrast enhanced(CE) CMR and 2-D echocardiography
imaging were performed in patients within 3+/-2 days
post STEMI. CMR-derived IS was measured from the
late CE images and AAR was measured from T2 black
blood images. SA was calculated as AAR/IS. Global
longitudinal (LS) and circumferential (CS) strain were
assessed from standard apical (16 segment model for
LS) or midventricular short axis views using 2-D
speckle-tracking software (2D CPA, TomTec, Germany).
Results
15 patients with STEMI completed the protocol. Age
was 50.8+/-12.6 years (86.7% male). Baseline LVEDV
was 203.4 +/- 51.7ml and EF was 51.1% +/- 14.7% with
follow up LVEDV 219.9 +/- 72.2ml (p=0.15) and EF
50.8% +/- 13.8% (p=0.8). Average IS was 16.4+/-10.4%,
AAR was 23.4+/-12.2%, and SA was 7.0+/-5.7% at base-
line. Baseline LS was -13.5 +/- 4.1 and CS was -19.4 +/-
6.3. Global longitudinal strain was associated with peak
troponin I levels (r=-0.74, P<0.001). Correlating LS and
CS to baseline MRI parameters showed a strong correla-
tion to LVEF (r=0.81 and 0.88 respectively, p<0.0001)
and IS (r=-0.68 and r=-0.69, p<0.001). There was mod-
erate correlation of LS and CS to LVEDV (r=-0.55 and
-0.57), p<0.05) and AAR (r=-0.61 and r=-0.57, p<0.05).
There was no correlation between strain and SA. There
were modest correlations between initial LS and change
in LVEDV but not with CS and change in LVEDV (r=-
0.61, p<0.05 and r=-0.48, p=0.07).
Conclusions
Echo strain measurements correlated most strongly with
LVEF and IS. There were modest associations between
strain at baseline and early LV remodeling.
Funding
None.
1Washington Hospital Center, Washington, DC, USA
Full list of author information is available at the end of the article
Weissman et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P25
http://www.jcmr-online.com/content/14/S1/P25
© 2012 Weissman et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.
Author details
1Washington Hospital Center, Washington, DC, USA. 2Case Western Reserve
University, Cleveland, OH, USA.
Published: 1 February 2012
doi:10.1186/1532-429X-14-S1-P25
Cite this article as: Weissman et al.: cMR in acute myocardial infarction:
correlation between myocardial scar and echocardiographic strain.
Journal of Cardiovascular Magnetic Resonance 2012 14(Suppl 1):P25.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit
Figure 1 Correlation between infarct size and longitudinal (LS) and
circumferential (CS) strain.
Weissman et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P25
http://www.jcmr-online.com/content/14/S1/P25
Page 2 of 2


Crossref

POSTER PRESENTATION Open AccesscMR in acute myocardial infarction: correlationbetween myocardial scar and echocardiographicstrainGaby Weissman1*, Michael Kern2, Ana Barac1, Manuel A Gonzalez1, Rebecca Torguson1, Ron Waksman1,Anthon Fuisz1From 15th Annual SCMR Scientific SessionsOrlando, FL, USA. 2-5 February 2012SummaryGlobal longitudinal and circumferential strain wasassessed by echo in 15 patients after acute MI. MRIparameters including ventricular volumes, scar, and areaat risk were assessed 3+/-2 days post STEMI and at 30day follow up. Echo strain measures correlated moststrongly with LVEF (r=0.81 and 0.88 longitudinal ad cir-cumferential strain, p<0.0001) and infarct size (r=-0.68and r=-0.69, p<0.001). There were moderate correlationsbetween longitudinal strain and change in LVEDV (r=-0.61, p<0.05).BackgroundCardiac MR (CMR) is a powerful tool in the evaluationmyocardial scar and volumes. Speckle tracking by echois used to evaluate myocardial strain. The correlationbetween strain measures and MR measures of scar isnot well defined.HypothesisCMR parameters, area at risk (AAR), infarct size (IS),and salvage area (SA), correlate with global echo strainin patients with a ST elevation MI (STEMI).MethodsContrast enhanced(CE) CMR and 2-D echocardiographyimaging were performed in patients within 3+/-2 dayspost STEMI. CMR-derived IS was measured from thelate CE images and AAR was measured from T2 blackblood images. SA was calculated as AAR/IS. Globallongitudinal (LS) and circumferential (CS) strain wereassessed from standard apical (16 segment model forLS) or midventricular short axis views using 2-Dspeckle-tracking software (2D CPA, TomTec, Germany).Results15 patients with STEMI completed the protocol. Agewas 50.8+/-12.6 years (86.7% male). Baseline LVEDVwas 203.4 +/- 51.7ml and EF was 51.1% +/- 14.7% withfollow up LVEDV 219.9 +/- 72.2ml (p=0.15) and EF50.8% +/- 13.8% (p=0.8). Average IS was 16.4+/-10.4%,AAR was 23.4+/-12.2%, and SA was 7.0+/-5.7% at base-line. Baseline LS was -13.5 +/- 4.1 and CS was -19.4 +/-6.3. Global longitudinal strain was associated with peaktroponin I levels (r=-0.74, P<0.001). Correlating LS andCS to baseline MRI parameters showed a strong correla-tion to LVEF (r=0.81 and 0.88 respectively, p<0.0001)and IS (r=-0.68 and r=-0.69, p<0.001). There was mod-erate correlation of LS and CS to LVEDV (r=-0.55 and-0.57), p<0.05) and AAR (r=-0.61 and r=-0.57, p<0.05).There was no correlation between strain and SA. Therewere modest correlations between initial LS and changein LVEDV but not with CS and change in LVEDV (r=-0.61, p<0.05 and r=-0.48, p=0.07).ConclusionsEcho strain measurements correlated most strongly withLVEF and IS. There were modest associations betweenstrain at baseline and early LV remodeling.FundingNone.1Washington Hospital Center, Washington, DC, USAFull list of author information is available at the end of the articleWeissman et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P25http://www.jcmr-online.com/content/14/S1/P25© 2012 Weissman et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the CreativeCommons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited.Author details1Washington Hospital Center, Washington, DC, USA. 2Case Western ReserveUniversity, Cleveland, OH, USA.Published: 1 February 2012doi:10.1186/1532-429X-14-S1-P25Cite this article as: Weissman et al.: cMR in acute myocardial infarction:correlation between myocardial scar and echocardiographic strain.Journal of Cardiovascular Magnetic Resonance 2012 14(Suppl 1):P25.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient online submission• Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submitFigure 1 Correlation between infarct size and longitudinal (LS) andcircumferential (CS) strain.Weissman et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P25http://www.jcmr-online.com/content/14/S1/P25Page 2 of 2

file:///data/core-remote/dit/data/Springer-OA/pdf/917/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjExODYvMTUzMi00MjlYLTE0LVMxLVAyNS5wZGY=.pdf

cMR in acute myocardial infarction: correlation between myocardial scar and echocardiographic strain

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Directory of Open Access Journals

Springer - Publisher Connector

Crossref