Abstract from the 22nd Clinical Congress of the American Society for Parenteral and Enteral Nutrition, Orlando, FL, January 18-21, 1998

Croft, M. E.

Gervasio, Jane M.

Hak, Emily B.

Hak, Lawrence J.

Storm, Michael C.

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Butler UniversityDigital Commons @ Butler UniversityScholarship and Professional Work – COPHS College of Pharmacy & Health Sciences1-1998Comparison of arterial plasma amino acidconcentrations in rats fed ad lib oral chow orparenteral nutrition via intravenous or gastricinfusionJane M. GervasioButler University, jgervasi@butler.eduEmily B. HakMichael C. StormM. E. CroftLawrence J. HakFollow this and additional works at: http://digitalcommons.butler.edu/cophs_papersPart of the Pharmacy and Pharmaceutical Sciences CommonsThis Article is brought to you for free and open access by the College of Pharmacy & Health Sciences at Digital Commons @ Butler University. It hasbeen accepted for inclusion in Scholarship and Professional Work – COPHS by an authorized administrator of Digital Commons @ Butler University.For more information, please contact fgaede@butler.edu.Recommended CitationGervasio, Jane M.; Hak, Emily B.; Storm, Michael C.; Croft, M. E.; and Hak, Lawrence J., "Comparison of arterial plasma amino acidconcentrations in rats fed ad lib oral chow or parenteral nutrition via intravenous or gastric infusion" (1998). Scholarship andProfessional Work – COPHS. Paper 28.http://digitalcommons.butler.edu/cophs_papers/28Comparison of arterial plasma amino acid concentrations in rats fed ad lib oral chow or parenteral nutrition via intravenous or gastric infusion !JM Gervasio, EB Hak, MC Storm, ME Croft, LJ Hak !!In a rat ischemic acute renal failure model, glycine may be protective to the kidney while lysine and alanine may be nephrotoxic. We have hypothesized that the arterial amino acid plasma pattern, total arterial amino acid concentrations, creatinine clearance, and urine calcium excretion in rats given the same formula via IV or gastrostomy tube continuously would differ. Carotid arterial lines and either an IV or gastrostomy tube were placed in Sprague-Dawley rats who were given parenteral nutrition IV (n = 9), parenteral nutrition via gastrostomy tube (n = 7) or ad lib oral chow (n = 9). After 3 days, arterial blood was drawn during the IV of gastrostomy tube infusion. The ad lib oral chow group was in the absorptive phase. Gastrostomy tube and ad lib oral chow rats gained 5.4 ± 4.6 and 6.8 ± 15 g, respectively, but IV rats lost 12 ± 19 g. Glycine concentrations (nmol/mL) in the IV and gastrostomy tube groups were more than twice the ad lib oral chow group. Alanine and lysine concentrations were not different. Total arterial amino acis were greater in the IV than in the ad lib oral chow group and tended to be greater in the IV group compared to the gastrostomy tube (p = 0.08).    Glycine  Alanine  Lysine  Total amino acids IV   721 ± 209a 571 ± 74 612 ± 126 5239 ± 439a Gastrostomy tube  607 ± 67 a 556 ± 102 682 ± 110 4888 ± 275a Ad lib oral chow  284 ± 57 457 ± 136 536 ± 140 3840 ± 705 P-value ≤ 0.05 = statistical significance; a = different from ad lib oral chow, b = different from gastrostomy tube. !!   Urine volume urine calcium Calcium excretion Urine creatinine cont’d.    ml  mg/dL  mg/d   mg/dL IV   22 ± 9a,b  1.3 ± 0.8 11.6 ± 1.2  17 ± 12a,b Gastrostomy tube  24 ± 4a  1.6 ± 1.2 11.6 ± 1.6  17 ± 7a Ad lib oral chow  13 ± 7b  7.2 ± 6.8 10.8 ± 1.1  56 ± 42b "1!   s creatinine Creatinine clearance    mg/dL  ml/min/100g IV   0.4 ± 0.1 0.28 ± 0.17 Gastrostomy tube  0.5 ± 0.1 0.28 ± 0.14 Ad lib oral chow  0.4 ± 0.1 0.58 ± 0.77 P-value ≤ 0.05 = statistical significance; a = different from ad lib oral chow, b = different from gastrostomy tube. !!We conclude that the total amino acid load presented to the kidney is great with IV than with ad lib chow and tends to be greater with IV than with gastrostomy tube infusion of the same parenteral nutrition formula. With parenteral nutrition, arterial glycine concentrations are greater than ad lib oral chow while arterial alanine and lysine concentrations are not different from ad lib oral chow."2

Comparison of arterial plasma amino acid concentrations in rats fed ad lib oral chow or parenteral nutrition via intravenous or gastric infusion

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Comparison of arterial plasma amino acid concentrations in rats fed ad lib oral chow or parenteral nutrition via intravenous or gastric infusion

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