Bianca Nedelcu

Geta Manea

Maria-Elena Cocuz

Rodica Silaghi

BMC Infectious Diseases

PubMed

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Metabolic complications during HIV-treatment
with protease inhibitors in patients from Braşov
Maria-Elena Cocuz1*, Rodica Silaghi2, Bianca Nedelcu2, Geta Manea2
From The 7th Romanian National HIV/AIDS Congress and The 2nd Central European HIV Forum
Sibiu, Romania. 29-31 May 2014
Objective: to evaluate the effects of treatment with pro-
tease inhibitors on serum level of triglycerides, choles-
terol and glycemia in HIV-infected patients, in assessing
the need of monitoring patients.
We performed a retrospective study on 25 patients
with HIV infection, in evidence of the Infectious Dis-
eases Hospital of Braşov, treated with protease inhibitors
in the treatment regimen. We studied the levels of cho-
lesterol, serum triglycerides and blood glucose at the
beginning and during treatment with protease inhibitors.
We found increases in serum cholesterol levels in 72%
of patients and in 83.33% of them were increasing by
50% from baseline; growth exceeded baseline in 44.45%
of cases. Serum triglycerides have increased to 68% of
patients, with up to 100% from baseline in 64.5% of
cases and in the rest of the patients the increase was
marked, beyond 100% exceeded normal values in 64.5%
of cases. Blood glucose was maintained at normal levels
in 56% patients and increased in 24% of cases.
Treatment with protease inhibitors is associated fre-
quently with increased serum levels of cholesterol and tri-
glycerides; hyperglycemia has rarely occurred. Patients
treated with protease inhibitors require rigorous monitor-
ing of the metabolism of fats and carbohydrates in order
to establish appropriate treatment for early complications
that may have occurred.
Authors’ details
1Faculty of Medicine, Transilvania University, Braşov, Romania. 2Infectious
Diseases Hospital, Braşov, Romania.
Published: 29 May 2014
doi:10.1186/1471-2334-14-S4-P32
Cite this article as: Cocuz et al.: Metabolic complications during HIV-
treatment with protease inhibitors in patients from Braşov. BMC
Infectious Diseases 2014 14(Suppl 4):P32.
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www.biomedcentral.com/submit1Faculty of Medicine, Transilvania University, Braşov, Romania
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Cocuz et al. BMC Infectious Diseases 2014, 14(Suppl 4):P32
http://www.biomedcentral.com/1471-2334/14/S4/P32
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Metabolic complications during HIV-treatment with protease inhibitors in patients from Braşov

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Metabolic complications during HIV-treatment with protease inhibitors in patients from Braşov

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