B Singh

CA Hyde

DA Jones

JL Nortier

JY Park

K Gohji

K Mitsui

K Nagatsuma

KS Pohar

LC Chen

LF Grey

LW Klee

Mei-Hui Lee

Ming-Feng Hou

ML Cher

N Bi

PP Grimminger

RG Mason

S Holmang

S Shum

Siou-Jin Chiu

T Hla

T Suzuki

TP Cheung

Tsu-Ming Chien

Wei-Chiao Chang

Wei-Pin Chang

Yii-Her Chou

YJ Kim

Yu-Shiuan Wang

Journal of Medical Case Reports

English

PubMed

Springer - Publisher Connector

Cox-2 gene overexpression in ureteral stump urothelial carcinoma following nephrectomy for renal cell carcinoma: a case report

Abstract
          
            Introduction
            A primary ureteral stump tumor after a nephrectomy is rare; urothelial carcinoma of the ureteral stump after a nephrectomy for renal cell carcinoma is even rarer. A thorough review of the literature indicated that only seven cases have previously been reported. In this study, we report the first Taiwanese case of urothelial carcinoma of the ureteral stump after a nephrectomy. It is also the first female case in the literature. The relationship between inflammatory genes, medication history and ureteral stump carcinoma after a nephrectomy for renal cell carcinoma has not been reported.
          
          
            Case presentation
            A 72-year-old Asian Taiwanese women with chronic hepatitis C, liver cirrhosis and chronic kidney disease underwent a hand-assisted laparoscopic radical nephrectomy in 2001 due to renal cell carcinoma. Nine years later, she was diagnosed with ureteral stump urothelial carcinoma. Genetic and medication surveys were performed. Importantly, our patient had taken Chinese herbal drugs for more than 10 years and the inflammatory gene, Cox-2, was highly expressed in this patient. This is the first report to study the relationship between the Cox-2 gene and ureteral stump carcinoma after a nephrectomy for renal cell carcinoma.
          
          
            Conclusion
            Long-term multiple use of Chinese herbal drugs could be one of the important risk factors for developing urothelial cancer. Close functional coupling between Chinese herbal drugs, Cox-2 gene activation and urothelial cancer should be further investigated.
          </jats:sec

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3299630

Cox-2 gene overexpression in ureteral stump urothelial carcinoma following nephrectomy for renal cell carcinoma: a case report

Abstract

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