Colin Powell

Geetinder Kaur

Paula Williamson

Rosalind Smyth

Trials

English

PubMed

Crossref

ORAL PRESENTATION Open AccessA survey of facilitators and barriers torecruitment to the magnetic trialGeetinder Kaur1*, Rosalind Smyth2, Colin Powell3, Paula Williamson1From 2nd Clinical Trials Methodology Conference: Methodology MattersEdinburgh, UK. 18-19 November 2013BackgroundRecruitment to randomised trials with children is challen-ging. It is imperative to understand the factors that boostor hinder recruitment to clinical trials. We conducted asurvey of facilitators and barriers to recruitment to theMAGNETIC trial, using a web-based tool previouslydeveloped (1).MethodMAGNETIC is a multi-centre randomised trial of nebu-lised magnesium in acute severe asthma, recruiting over500 children from 30 UK sites. Recruiters were asked tograde a list of factors from -3 to +3 depending on whetherthe factor was perceived as a strong, intermediate, or weakbarrier (-3 to -1) or facilitator (+1 to+3) and (0) if thoughtto be not applicable. Free text responses were invited onstrategies applied to counter the identified barriers andsuggestions on future reorganisation of similar trials.We plan to look for correlation between responses andcalibrated recruitment performance at sites.ResultsThe commonly identified facilitators were motivationand experience of study team, effective communication,presence of designated research nurses, good trial man-agement, trial publicity and clarity in presentation oftrial information. The commonly identified barrierswere clinical workload, shift patterns, time and settingof consent, GCP training, non-availability of researchstaff out of hours and parents’ concerns about theirchild taking an experimental medicine.ConclusionsThis study highlights important generic and trial-specificfacilitators and barriers to recruitment to a paediatrictrial in the acute setting. This information can be veryuseful for successful conduct of future clinical trialswith children.Authors’ details1University of Liverpool, Liverpool, UK. 2University College London (UCL),London, UK. 3Children’s Hospital for Wales, Cardiff, UK.Published: 29 November 2013Reference1. Kaur G, Smyth RL, Williamson PR: Developing a survey of barriers andfacilitators to recruitment in randomized controlled trials. Trials 2012,13:218.doi:10.1186/1745-6215-14-S1-O60Cite this article as: Kaur et al.: A survey of facilitators and barriers torecruitment to the magnetic trial. Trials 2013 14(Suppl 1):O60.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient online submission• Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submit1University of Liverpool, Liverpool, UKFull list of author information is available at the end of the articleKaur et al. Trials 2013, 14(Suppl 1):O60http://www.trialsjournal.com/content/14/S1/O60 TRIALS© 2013 Kaur et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited.

A survey of facilitators and barriers to recruitment to the magnetic trial

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ORAL PRESENTATION Open Access
A survey of facilitators and barriers to
recruitment to the magnetic trial
Geetinder Kaur1*, Rosalind Smyth2, Colin Powell3, Paula Williamson1
From 2nd Clinical Trials Methodology Conference: Methodology Matters
Edinburgh, UK. 18-19 November 2013
Background
Recruitment to randomised trials with children is challen-
ging. It is imperative to understand the factors that boost
or hinder recruitment to clinical trials. We conducted a
survey of facilitators and barriers to recruitment to the
MAGNETIC trial, using a web-based tool previously
developed (1).
Method
MAGNETIC is a multi-centre randomised trial of nebu-
lised magnesium in acute severe asthma, recruiting over
500 children from 30 UK sites. Recruiters were asked to
grade a list of factors from -3 to +3 depending on whether
the factor was perceived as a strong, intermediate, or weak
barrier (-3 to -1) or facilitator (+1 to+3) and (0) if thought
to be not applicable. Free text responses were invited on
strategies applied to counter the identified barriers and
suggestions on future reorganisation of similar trials.
We plan to look for correlation between responses and
calibrated recruitment performance at sites.
Results
The commonly identified facilitators were motivation
and experience of study team, effective communication,
presence of designated research nurses, good trial man-
agement, trial publicity and clarity in presentation of
trial information. The commonly identified barriers
were clinical workload, shift patterns, time and setting
of consent, GCP training, non-availability of research
staff out of hours and parents’ concerns about their
child taking an experimental medicine.
Conclusions
This study highlights important generic and trial-specific
facilitators and barriers to recruitment to a paediatric
trial in the acute setting. This information can be very
useful for successful conduct of future clinical trials
with children.
Authors’ details
1University of Liverpool, Liverpool, UK. 2University College London (UCL),
London, UK. 3Children’s Hospital for Wales, Cardiff, UK.
Published: 29 November 2013
Reference
1. Kaur G, Smyth RL, Williamson PR: Developing a survey of barriers and
facilitators to recruitment in randomized controlled trials. Trials 2012,
13:218.
doi:10.1186/1745-6215-14-S1-O60
Cite this article as: Kaur et al.: A survey of facilitators and barriers to
recruitment to the magnetic trial. Trials 2013 14(Suppl 1):O60.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit1University of Liverpool, Liverpool, UK
Full list of author information is available at the end of the article
Kaur et al. Trials 2013, 14(Suppl 1):O60
http://www.trialsjournal.com/content/14/S1/O60 TRIALS
© 2013 Kaur et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


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A survey of facilitators and barriers to recruitment to the magnetic trial

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