Andreas Melzer

Ioannis Karakitsios

Journal of Therapeutic Ultrasound

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MEETING ABSTRACT Open Access
PRF Thermometry during MR-guided Focused
Ultrasound Ablation in a Preclinical Thiel Model
Ioannis Karakitsios*, Andreas Melzer
From 2nd European Symposium on Focused Ultrasound Therapy
Rome, Italy. 10-11 October 2013
Background
MR guided Focused Ultrasound Surgery (MRgFUS) is a
widely accepted treatment option that utilizes MR ima-
ging for treatment planning, and Focused Ultrasound to
ablate tumour and significantly reduce its size. Proton
Resonance Frequency (PRF) Thermometry method is a
useful tool for treatment planning, as it provides with
accurate, real-time temperature maps. The aim of the
present study was to determine the accuracy PRF Ther-
mometry during MRgFUS on explanted Thiel embalmed
human and animal liver, fresh animal liver, and compare
to polyacrylamide gel phantom.
Materials and methods
PRF Thermometry was conducted on 1.5T MRI system
(Signa HDx, GE Medical Systems, Milwaukee, WI, USA)
with embedded FUS table (ExAblate 2000 Uterine Fibroid
System, InSightec Ltd., Tirat Carmel, Israel). The phantom
and the organs were sonicated for 20 seconds using the
following acoustic protocols: 300J, 600J, 1000J and 1400J.
The temperature rise which based on PRF Thermometry
during sonication was compared to the actual temperature
increase in the same conditions measured by fibre optic
thermocouples.
Results
For the Thiel embalmed organs, we found temperature
difference varied from 1.17°C to 3.13°C for the ovine
liver, and from 1.30°C to 3.10°C for the human liver.
The treatment of both fresh animal liver and phantom
resulted in temperature differences lower 0.40°C.
Conclusion
Our results indicated that PRF Thermometry is accurate
on fresh animal tissue, as the temperature differences
measured in the fresh organ were low and similar to those
found for the gel phantom, and this was in accordance
with published studies. However, the temperature differ-
ences found in the Thiel embalmed organs were higher
than the fresh organ. This shows that the Thiel embalming
affects temperature distribution in the organ. Thus, PRF-
based temperature calibration of the Focused Ultrasound
machine for Thiel embalmed tissue is highly desirable.
However, the similarity of temperature difference between
the Thiel human and Thiel animal organs could facilitate
the utilization of Thiel animal organs for studies involving
temperature monitoring during MRgFUS ablations.
Published: 10 December 2014
doi:10.1186/2050-5736-2-S1-A11
Cite this article as: Karakitsios and Melzer: PRF Thermometry during MR-
guided Focused Ultrasound Ablation in a Preclinical Thiel Model. Journal
of Therapeutic Ultrasound 2014 2(Suppl 1):A11.
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Karakitsios and Melzer Journal of Therapeutic Ultrasound 2014, 2(Suppl 1):A11
http://www.jtultrasound.com/content/2/S1/A11
© 2014 Karakitsios and Melzer; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


PRF Thermometry during MR-guided Focused Ultrasound Ablation in a Preclinical Thiel Model

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PRF Thermometry during MR-guided Focused Ultrasound Ablation in a Preclinical Thiel Model

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