Min Liu

Tian Zhang

Xiaojuan Guo

Yuanhua Yang

Journal of Cardiovascular Magnetic Resonance

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POSTER PRESENTATION Open Access
Longitudinal strain correlated with
haemodynamics in patients with chronic
thromboembolic pulmonary hypertension
Min Liu1*, Tian Jing Zhang2, Xiaojuan Guo1, Yuanhua Yang3
From 19th Annual SCMR Scientific Sessions
Los Angeles, CA, USA. 27-30 January 2016
Background
To determine the feasibility of the longitudinal strain
assessed by Trufistrain on four-chamber images of Cardiac
MRI in patients with chronic thromboembolic pulmo-
nary hypertension and to correlate with right heart
catheterization.
Methods
After informed consent, 36 patients (age, 45.9 ± 10.1 years;
male/female= 25/11, Heart rate=65 ± 8bpm) with chronic
thromboembolic pulmonary hypertension (CTEPH)
underwent CMRI at 3T (TimTrio, Siemens) and right
heart catheterization in the same day. After Four-chamber
cine images were acquired during short breath-holds with
a retrospectively gated turbo FLASH gradient-echo
sequence and the longitudinal strain independently
measured by two radiologists on four-chamber cine
images with Trufistrain (Siemens). The hemodynamics
was evaluated with right heart catheterization. The feasi-
bility of the longitudinal strain assessed by Trufistrain.
The feasibility of strain evaluated with Trufistrain were
assessed with A Bland-Altman plot and correlation of
strain with hemodynamics was evaluated with Spearman
correlation on Medicalc and SPSS
Results
A Bland-Altman plot (Figure 1a) of the longitudinal
strain measurements twice showed that the bias was
only -0.06 and the interclass correlation coefficient is
0.99 (p < 0.001). A Bland-Altman plot (Figure 1b) of the
longitudinal strain measurements by two observers
showed that the bias was only -0.08 and the interclass
correlation coefficient is 0.96 (p < 0.001). The mean
longitudinal strain on 4-chamber cine images (Fig1c and
1d)was -7.20 ± 5.18%, correlating with systolic PAP (r =
0.533,P=0.11), diastolic PAP (r = 0.479,p=0.024), mean
PAP (r = 0.575,P=0.005), Cardiac Output (r=-0.500,
p=0.018) and pulmonary vascular resistance (r = 0.785,
p < 0.001),but did not correlate with PCWP (R=-0.223,
P=0.203) and CI (r=-0.355,p=0.105).
Conclusions
In this work, we demonstrated the feasibility of the longi-
tudinal strain measurement on Cine images by Trufistrain.
And the longitudinal strain correlated with PAP, CO and
PVR. These suggest longitudinal strain measurement on
Cine images by Trufistrain is promising to assess hemody-
namics. In the future, we will analyze the correlation of
longitudinal strain with myocardial function and fibrosis.
Authors’ details
1Radiology, Beijing Chaoyang Hospital of Capital Medical University, Beijing,
China. 2MR Collaborations NE Asia, Siemens Healthcare, Beijing, China.
3Respiratory Diseases Research Center, Beijing Chaoyang Hospital of Capital
Medical University, Beijing, China.
Published: 27 January 2016
doi:10.1186/1532-429X-18-S1-P299
Cite this article as: Liu et al.: Longitudinal strain correlated with
haemodynamics in patients with chronic thromboembolic pulmonary
hypertension. Journal of Cardiovascular Magnetic Resonance 2016 18(Suppl 1):
P299.
1Radiology, Beijing Chaoyang Hospital of Capital Medical University, Beijing,
China
Full list of author information is available at the end of the article
Liu et al. Journal of Cardiovascular Magnetic
Resonance 2016, 18(Suppl 1):P299
http://www.jcmr-online.com/content/18/S1/P299
© 2016 Liu et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://
creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the
original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/
zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Figure 1 showed the feasibility of the longitudinal strain was assessed with Trufistrain in twice on Figure 1a and by two readers on
Figure 1b. The longitudinal strain on the four-chamber image on Figre 1c and the segmental and global longitudinal strain on Figure 1d were
assessed with Trufistrain
Liu et al. Journal of Cardiovascular Magnetic
Resonance 2016, 18(Suppl 1):P299
http://www.jcmr-online.com/content/18/S1/P299
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Longitudinal strain correlated with haemodynamics in patients with chronic thromboembolic pulmonary hypertension

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Longitudinal strain correlated with haemodynamics in patients with chronic thromboembolic pulmonary hypertension

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