Simon M Vogt

Ulrich G Hofmann

BMC Neuroscience

English

PubMed

Springer - Publisher Connector

POSTER PRESENTATION Open Access
A unifying perspective on neuromodulatory
effects on signal transmission and plasticity in
D1-dominant MSN neurons
Simon M Vogt1,2*, Ulrich G Hofmann1
From Twenty Second Annual Computational Neuroscience Meeting: CNS*2013
Paris, France. 13-18 July 2013
How could phasic variations in dopamine level affect the
learning outcome of a spiking neural network? How may
neuromodulation affect the network’s instantaneous
response to simultaneously arriving glutamatergic inputs?
How may this depend on the brain regions involved?
In our spiking phenomenological model for signal trans-
mission across the synapse and along the dendritic tree,
we propose a new approach for the influence of dopa-
mine-like neuromodulators on the ascribed aspects, which
unifies diverging views on its role in (reinforcement) learn-
ing and (attentional) contrast.
We call into question the common practice of simulat-
ing dopaminergic influence on an STDP rule as a third
factor, and instead show how an instantaneous effect of a
dopamine-like neuromodulator on postsynaptic activity
can also lead to reinforced learning outcomes.
As the phasic change of neuromodulator needs to be
present during glutamatergic transmission in our model,
we do not account for delayed reward as stated in the dis-
tal reward problem. Instead, we assume an involvement of
hippocampus and cortical working memory for long
delays of reward. However, as our transmission-based
model does not interfere with the standard two-factor
STDP rule, it may be freely combined with existing exten-
sions to STDP if needed.
Author details
1AG Neuroelectronic Systems, University Clinic Freiburg, 79108 Freiburg,
Germany. 2Institute for Signal Processing, University of Lübeck, 23562 Lübeck,
Germany.
Published: 8 July 2013
References
1. Schultz W, Dayan P, Montague PR: A neural substrate of prediction and
reward. Science 1997, 275(5306):1593.
2. Berridge KC, Robinson TE: What is the role of dopamine in reward:
hedonic impact, reward learning, or incentive salience? Brain research
Brain research reviews 1998, 28(3):309-369.
3. Nicola SM, Hopf FW, Hjelmstad GO: Contrast enhancement: a
physiological effect of striatal dopamine? Cell and tissue research 2004,
318(1):93-106.
4. Thurley K, Senn W, Lüscher HR: Dopamine increases the gain of the
input-output response of rat prefrontal pyramidal neurons. Journal of
neurophysiology 2008, 99(6):2985-2997.
5. Kroener S, Chandler LJ, Phillips PEM, Seamans JK: Dopamine modulates
persistent synaptic activity and enhances the signal-to-noise ratio in the
prefrontal cortex. PloS One 2009, 4(8):6507.
6. Masquelier T, Guyonneau R, Thorpe SJ: Spike timing dependent plasticity
finds the start of repeating patterns in continuous spike trains. PloS one
2008, 3(1):1377.
7. Shen W, Flajolet M, Greengard P, Surmeier DJ: Dichotomous dopaminergic
control of striatal synaptic plasticity. Science 2008, 321(5890):848-851.
8. Morrison A, Diesmann M, Gerstner W: Phenomenological models of
synaptic plasticity based on spike timing. Biological cybernetics 2008,
98(6):459-478.
9. Izhikevich EM: Solving the distal reward problem through linkage of
STDP and dopamine signaling. Cerebral cortex 2007, 17(10):2443-2452.
10. Vogt SM, Hofmann UG: Neuromodulation of STDP through short-term
changes in firing causality. Cognitive Neurodynamics 2012, 6(4):353-366.
doi:10.1186/1471-2202-14-S1-P172
Cite this article as: Vogt and Hofmann: A unifying perspective on
neuromodulatory effects on signal transmission and plasticity in
D1-dominant MSN neurons. BMC Neuroscience 2013 14(Suppl 1):P172.
* Correspondence: vogt@isip.uni-luebeck.de
1AG Neuroelectronic Systems, University Clinic Freiburg, 79108 Freiburg,
Germany
Full list of author information is available at the end of the article
Vogt and Hofmann BMC Neuroscience 2013, 14(Suppl 1):P172
http://www.biomedcentral.com/1471-2202/14/S1/P172
© 2013 Vogt and Hofmann; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.


A unifying perspective on neuromodulatory effects on signal transmission and plasticity in D1-dominant MSN neurons

Crossref

http://dx.doi.org/10.1186/1471-2202-14-S1-P172

A unifying perspective on neuromodulatory effects on signal transmission and plasticity in D1-dominant MSN neurons

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Crossref

Springer - Publisher Connector