Accelerated pipeline for DNA and amino acid sequences clustering

Kelly A. Brayton

Shira L. Broschat

Svetlana Lockwood

BMC Genomics

Background: Multiple important human and livestock pathogens employ ticks as their primary host vectors. It is not currently known whether this means of infecting a host arose once or many times during evolution.  Results: In order to address this question, we conducted a comparative genomics analysis on a set of bacterial pathogens from seven genera - Borrelia, Rickettsia, Anaplasma, Ehrlichia, Francisella, Coxiella, and Bartonella, including species from three different host vectors - ticks, lice, and fleas. The final set of 102 genomes used in the study encoded a total of 120,046 protein sequences. We found that no genes or metabolic pathways were present in all tick-borne bacteria. However, we found some genes and pathways were present in subsets of tick-transmitted organisms while absent from bacteria transmitted by lice or fleas.  Conclusion: Our analysis suggests that the ability of pathogens to be transmitted by ticks arose multiple times over the course of evolution. To our knowledge, this is the most comprehensive study of tick transmissibility to date.Published copyLockwood, S., K.A. Brayton, and S. L. Broschat. Comparative genomics reveals multiple pathways to mutualism for tick-borne pathogens. BMC Genomics, Vol.17, No. 481, Jul. 2016. doi:10.1186/s12864-016-2744-9. PMCID: PMC4930560

Lockwood, Svetlana

Brayton, Kelly A.

Broschat, Shira L.

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Comparative genomics reveals multiple pathways to mutualism for tick-borne pathogens

Accelerated pipeline for DNA and amino acid sequences clustering.This is a pre-print

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Svetlana Lockwood (193901)

Kelly Brayton (3523091)

Shira Broschat (3530111)

The Francis Crick Institute

Additional file 2 of Comparative genomics reveals multiple pathways to mutualism for tick-borne pathogens

Accelerated pipeline for DNA and amino acid sequences clustering.

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Lockwood, Svetlana (5287387)

Broschat, Shira L. (5287390)

Brayton, Kelly A. (5287393)

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Comparative genomics reveals multiple pathways to mutualism for tick-borne pathogens

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NEUROSURGERY ENTHUSIASTIC WOMEN SOCIETY

Springer - Publisher Connector

The Francis Crick Institute

Springer - Publisher Connector

The Francis Crick Institute