Summary of QUIPS quality assessment domains (60 studies). (DOCX 54Â kb

Carol A. Forbes

Gill Worthy

Jos Kleijnen

Lisa Stirk

Nathan D. Wong

Robert Wolff

Ruben G. W. Quek

Shravanthi R. Gandra

Sohan Deshpande

Stephen Djedjos

Lipids in Health and Disease

PubMed

Springer - Publisher Connector

The relationship between Lp(a) and CVD outcomes: a systematic review

Robust associations between lipoprotein(a) [Lp(a)] and CVD outcomes among general populations have been published in previous studies. However, associations in high risk primary prevention and secondary prevention populations are less well defined. In order to investigate this further, a systematic review was performed including prospective studies, which assessed the relationship between Lp(a) and CVD outcomes using multivariable analyses. Additional information was gathered on Lp(a) assays, multivariable modelling and population characteristics. Literature searches from inception up to December 2015 retrieved 2850 records. From these 60 studies were included. Across 39 primary prevention studies in the general population (hazard ratios ranged from 1.16 to 2.97) and seven high risk primary prevention studies (hazard ratios ranged from 1.01 to 3.7), there was evidence of a statistically significant relationship between increased Lp(a) and an increased risk of future CVD. Results in 14 studies of secondary prevention populations were also suggestive of a modest statistically significant relationship (hazard ratios ranged from 0.75 to 3.7). Therefore current evidence would suggest that increased Lp(a) levels are associated with modest increases in the risk of future CVD events in both general and higher risk populations. However, further studies are required to confirm these findings

Forbes, Carol A.

Quek, Ruben G. W.

Deshpande, Sohan

Worthy, Gill

Wolff, Robert

Stirk, Lisa

Kleijnen, Jos

Gandra, Shravanthi R.

Djedjos, Stephen

Wong, Nathan D.

NARCIS 

Carol Forbes (3470894)

Ruben Quek (3470906)

Sohan Deshpande (3470897)

Gill Worthy (88939)

Robert Wolff (389391)

Lisa Stirk (49242)

Jos Kleijnen (261742)

Shravanthi Gandra (3470900)

Stephen Djedjos (3470909)

Nathan Wong (3470903)

The Francis Crick Institute

Additional file 3: Table S2. of The relationship between Lp(a) and CVD outcomes: a systematic review

Maastricht University Research Portal

Robust associations between lipoprotein(a) [Lp(a)] and CVD outcomes among general populations have been published in previous studies. However, associations in high risk primary prevention and secondary prevention populations are less well defined. In order to investigate this further, a systematic review was performed including prospective studies, which assessed the relationship between Lp(a) and CVD outcomes using multivariable analyses. Additional information was gathered on Lp(a) assays, multivariable modelling and population characteristics. Literature searches from inception up to December 2015 retrieved 2850 records. From these 60 studies were included. Across 39 primary prevention studies in the general population (hazard ratios ranged from 1.16 to 2.97) and seven high risk primary prevention studies (hazard ratios ranged from 1.01 to 3.7), there was evidence of a statistically significant relationship between increased Lp(a) and an increased risk of future CVD. Results in 14 studies of secondary prevention populations were also suggestive of a modest statistically significant relationship (hazard ratios ranged from 0.75 to 3.7).Therefore current evidence would suggest that increased Lp(a) levels are associated with modest increases in the risk of future CVD events in both general and higher risk populations. However, further studies are required to confirm these findings

The relationship between Lp(a) and CVD outcomes: a systematic review

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