NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

Aichinger; Antony Hynes-Allen; Axel Behrens; Azuara; Barbosa-Morais; Benjamini; Berger; Bernstein; Boyer; Brian Hendrich; Cao; Chou; Christophersen; Czermin; Donna Leaford; Du; Dunning; Faust; Gayan Balasooriya; Gentleman; Hanna; Heidi Dvinge; Hendrich; Irizarry; Isono; Jenuwein; Jung; Kaji; Kaji; Kashiwagi; Kauffmann; Kehle; Kelly; Kouzarides; Kuzmichev; Landeira; Langmead; Leeb; Lessard; Liang; Lou; Mali Salmon-Divon; McDonel; Mikkelsen; Montgomery; Morey; Muller; Muller; Nicola Reynolds; Niwa; O‧Carroll; Pardo; Pasini; Pasini; Pasini; Paul Bertone; Peng; Pera; Pruitt; Rice; Roh; Salmon-Divon; Shahbazian; Shen; Shin; Silva; Smyth; Stock; Tie; Unhavaithaya; van den Berg; Verrou; Voncken; Wang; Williams; Xu; Yoshida; Zhang; Zhang; Zhang

NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

Abstract

The NURD and Polycomb complexes PRC1 and PRC2 have been implicated in stem cell differentiation although their molecular roles are unclear. This study identifies a common set of genes that are sequentially regulated by these complexes, the NURD complex deacetylates H3K27 as a prerequisite for subsequent methylation by PRC2

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info:doi/10.1038%2Femboj.2011....

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