Deep eutectic solvent(s) (DES) are the new generation of greener and more sustainable solvents, formulated by the complex of hydrogen bond in the molecules. The solvents allow us to achieve a significantly lower freezing point compared to its components, an affordable formulation and a technology that is typically formulated to improve the bioavailability of a drug. In this research project, we synthesized an ibuprofen-menthol based therapeutic deep eutectic solvent and investigated how water content affects the structure and dynamics of the solvent. For synthesizing the ibuprofen-menthol DES, 2.0629 g of Ibuprofen and 4.6881 g of menthol were placed in a small breaker to achieve a 1:3 molar ratio. The mixer was covered by parafilm paper and was then heated on a hot plate at temperature of 50 ºC with 600 rpm for 30 minutes until a clear liquid was observed. In the infrared spectrum of the DES, a strong C-H stretching is noticed at 2800-2950 cm-1, OH bonds at 3345.57 cm-1 which involves in hydrogen bonding, and a less strong peak for the C=O stretching is detected at 1708.41 cm-1. Raman spectroscopy results showed that 10% and 20 % of water do not interrupt the ibuprofen-menthol’s Raman shift compared to the pure DES, however, significant change is observed while 30% and 40 % water were added to the system
