Invited TalkBone allograft is the most widely accepted approach in treating patients suffering from large segmental bone defect regardless of the advancement of synthetic bone substitutes[ I, 2]. However, the long-term complications of allograft application in term of delayed union or even nonunion were reported due to the stringent sterilization process prior to clinical implantation[3, 4]. Our previous studies demonstrated that the incorporation of magnesium ions (Mg2+) into biomaterials could …postprin
