We report a measurement of the B 0 → ψ(2S)π 0 branching fraction based on the full Υ(4S) data set of 772 × 106 BB¯ pairs collected by the Belle detector at the KEKB asymmetric-energy e +e − collider. We obtain B(B 0 → ψ(2S)π 0 ) = (1.17 ± 0.17(stat) ± 0.08(syst)) × 10−5 . The result has a significance of 7.2 standard deviations and is the first observation of the decay B 0 → ψ(2S)π 0
