Physiological type I collagen organization induces the formation of a novel class of linear invadosomes

Abstract

This study shows that fibrillar collagen I is the physiological inducer of a novel class of invadosomes, which we named “linear invadosomes.” They are dependent on the scaffold protein Tks5 and are able to degrade extracellular matrix elements. Moreover, we demonstrate that they are β1- and β3-integrin independent, unlike classical invadosomes