Gomes, Ana L

Gomes, Manuel

Matafome, Paulo C

Santos, Lélita C

Sarmento, Ana B

Seiça, Raquel F

English

PubMed

Paulo C Matafome

Ana L Gomes

Manuel Gomes

Lélita C Santos

Ana B Sarmento

Raquel F Seiça

Springer - Publisher Connector

Obesity and breast cancer: inflammatory and adipocytokine correlations

POSTER PRESENTATION Open Access
Obesity and breast cancer: inflammatory and
adipocytokine correlations
Paulo C Matafome1,2,3,6*, Ana L Gomes1, Manuel Gomes4, Lélita C Santos4, Ana B Sarmento5,6, Raquel F Seiça1,3,6
From 16th International Charles Heidelberger Symposium on Cancer Research
Coimbra, Portugal. 26–28 September 2010
Obesity is a chronic disease affecting millions of indivi-
duals around the world and has taken epidemic propor-
tions. Often, obesity is associated with other risk factors
such as hypertension and dyslipidemia, increasing meta-
bolic syndrome- related complications. Such complica-
tions include several cancer types, namely breast cancer.
Several mechanisms are likely to be involved in cancer
development and progression, however obesity as been
proved to be a risk factor. This study was designed in
order to analyse metabolic, inflammatory and oxidative
stress correlations between obesity and breast cancer,
studying three groups of patients: obesity, breast cancer
and obesity plus breast cancer.
Our results revealed no significant metabolic changes
between groups, despite some increased glycemia and
lipid levels were observed in obesity plus cancer group.
Furthermore, obesity plus cancer patients showed
increased fasting insulin levels and insulin resistance.
Regarding inflammatory biomarkers there were observed
no differences in TNF-alpha, IL-6, IL-8 and IL-10. How-
ever, MCP-1 levels were found to be increased in obese
patients with cancer, suggesting an involvement in obe-
sity- associated tumours. Serum levels of adiponectin
were similar in all groups and leptin levels were directly
correlated with the BMI. However, resistin levels were
increased in obese plus cancer group following MCP-1
profile.
This work revealed some biological markers of breast
cancer in obese woman, suggesting dysfunctional adi-
pose tissue as the link between obesity and cancer.
Author details
1Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra,
Portugal. 2Center of Ophthalmology, Faculty of Medicine, University of
Coimbra, Coimbra, Portugal. 3Institute of Biomedical Research in Light and
Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
4Department of Internal Medicine, University Hospitals, Coimbra, Portugal.
5Institute of Biochemistry, Faculty of Medicine, University of Coimbra,
Coimbra, Portugal. 6CIMAGO, Faculty of Medicine, University of Coimbra,
Coimbra, Portugal.
Published: 24 September 2010
doi:
Cite this article as: Matafome et al.: Obesity and breast cancer:
inflammatory and adipocytokine correlations. BMC Proceedings 2010 4
(Suppl 2):P5.
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* Correspondence: paulomatafome@gmail.com
1Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra,
Portugal
Full list of author information is available at the end of the article
Matafome et al. BMC Proceedings 2010, 4(Suppl 2):P5
http://www.biomedcentral.com/1753-6561/4/S2/P5
© 2010 Matafome et al; licensee BioMed Central Ltd.


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Obesity and breast cancer: inflammatory and adipocytokine correlations

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