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A Kruuner

AC Schurch

AG Tsolaki

AG van der Zanden

B Lopez

BA Lindstedt

Bing Lu

C Allix-Beguec

C Sola

Christine Pourcel

D Alland

D Cowley

D van Soolingen

DD Anh

Dick van Soolingen

E Yokoyama

EJ Feil

F Drobniewski

G Vergnaud

Gilles Vergnaud

H Dong

H Oota

Haiyan Dong

HY Huang

HY Kang

I Comas

I Filliol

I Mokrousov

I Parwati

Igor Mokrousov

J Kamerbeek

J Millet

J Wang

JD van Embden

Jie Liu

Jinghua Liu

JR Glynn

K Brudey

K Kremer

Kanglin Wan

Kristin Kremer

L Flores

L Grode

L Qian

LS Cowan

M Caws

M Fabre

MB Reed

N Kurepina

N Smittipat

NE Kurepina

P Le Flèche

P Supply

PJ Bifani

PR Hunter

R Brosch

R Frothingham

R Hershberg

RM Warren

RS Spurgiesz

S Gagneux

S Maeda

T Iwamoto

T Wada

T Wirth

WW Jiao

X Li

Xiuqin Zhao

Y Hauck

Y Murase

Yi Jiang

Yolande Hauck

Yuanyuan Zhang

Zhiguang Liu

English

PubMed

Liu, J.

Hauck, Y.

Zhang, Y.

Zhao, X.

Liu, Z.

Lu, B.

Dong, H.

Jiang, Y.

Kremer, K.

Vergnaud, G.

Soolingen, D. van

Pourcel, C.

NARCIS 

Investigation on Mycobacterium tuberculosis diversity in China and the origin of the Beijing clade

Radboud Repository

 in China has shown that Beijing genotype strains play a dominant role in the tuberculosis (TB) epidemic. In order to examine the strain diversity in the whole country, and to study the evolutionary development of Beijing strains, we sought to genotype a large collection of isolates using different methods.We applied a 15-loci VNTR typing analysis on 1,586 isolates from the Beijing municipality and 12 Chinese provinces or autonomous regions. The data was compared to that of 900 isolates from various other worldwide geographic regions outside of China. A total of 1,162/1,586 (73.2%) of the isolates, distributed into 472 VNTR types, were found to belong to the Beijing genotype family and this represented 56 to 94% of the isolates in each of the localizations. VNTR typing revealed that the majority of the non-Beijing isolates fall into two genotype families, which represented 17% of the total number of isolates, and seem largely restricted to China. A small number of East African Indian genotype strains was also observed in this collection. Ancient Beijing strains with an intact region of difference (RD) 181, as well as strains presumably resembling ancestors of the whole Beijing genotype family, were mainly found in the Guangxi autonomous region. VNTR-based genotyping study performed in China to date. The high percentage of Beijing isolates in the whole country and the presence in the South of strains representing early branching points may be an indication that the Beijing lineage originated from China, probably in the Guangxi region. Two modern lineages are shown here to represent the majority of non-Beijing Chinese isolates. The observed geographic distribution of the different lineages within China suggests that natural frontiers are major factors in their diffusion

Wan Kanglin

Liu Jinghua

Hauck Yolande

Zhang Yuanyuan

Liu Jie

Zhao Xiuqin

Liu Zhiguang

Lu Bing

Dong Haiyan

Jiang Yi

Kremer Kristin

Vergnaud Gilles

van Soolingen Dick

Pourcel Christine

Public Library of Science (PLOS)

 Diversity in China and the Origin of the Beijing Clade

International audienceBACKGROUND: Investigation of the genetic diversity of Mycobacterium tuberculosis in China has shown that Beijing genotype strains play a dominant role in the tuberculosis (TB) epidemic. In order to examine the strain diversity in the whole country, and to study the evolutionary development of Beijing strains, we sought to genotype a large collection of isolates using different methods. METHODOLOGY/PRINCIPAL FINDINGS: We applied a 15-loci VNTR typing analysis on 1,586 isolates from the Beijing municipality and 12 Chinese provinces or autonomous regions. The data was compared to that of 900 isolates from various other worldwide geographic regions outside of China. A total of 1,162/1,586 (73.2%) of the isolates, distributed into 472 VNTR types, were found to belong to the Beijing genotype family and this represented 56 to 94% of the isolates in each of the localizations. VNTR typing revealed that the majority of the non-Beijing isolates fall into two genotype families, which represented 17% of the total number of isolates, and seem largely restricted to China. A small number of East African Indian genotype strains was also observed in this collection. Ancient Beijing strains with an intact region of difference (RD) 181, as well as strains presumably resembling ancestors of the whole Beijing genotype family, were mainly found in the Guangxi autonomous region. CONCLUSIONS/SIGNIFICANCE: This is the largest M. tuberculosis VNTR-based genotyping study performed in China to date. The high percentage of Beijing isolates in the whole country and the presence in the South of strains representing early branching points may be an indication that the Beijing lineage originated from China, probably in the Guangxi region. Two modern lineages are shown here to represent the majority of non-Beijing Chinese isolates. The observed geographic distribution of the different lineages within China suggests that natural frontiers are major factors in their diffusion

Wan, Kanglin

Liu, Jinghua

Hauck, Yolande

Zhang, Yuanyuan

Liu, Jie

Zhao, Xiuqin

Liu, Zhiguang

Lu, Bing

Dong, Haiyan

Jiang, Yi

Kremer, Kristin

Vergnaud, Gilles

van Soolingen, Dick

Pourcel, Christine

HAL Descartes

Investigation on Mycobacterium tuberculosis Diversity in China and the Origin of the Beijing Clade.

BackgroundInvestigation of the genetic diversity of Mycobacterium tuberculosis in China has shown that Beijing genotype strains play a dominant role in the tuberculosis (TB) epidemic. In order to examine the strain diversity in the whole country, and to study the evolutionary development of Beijing strains, we sought to genotype a large collection of isolates using different methods.Methodology/principal findingsWe applied a 15-loci VNTR typing analysis on 1,586 isolates from the Beijing municipality and 12 Chinese provinces or autonomous regions. The data was compared to that of 900 isolates from various other worldwide geographic regions outside of China. A total of 1,162/1,586 (73.2%) of the isolates, distributed into 472 VNTR types, were found to belong to the Beijing genotype family and this represented 56 to 94% of the isolates in each of the localizations. VNTR typing revealed that the majority of the non-Beijing isolates fall into two genotype families, which represented 17% of the total number of isolates, and seem largely restricted to China. A small number of East African Indian genotype strains was also observed in this collection. Ancient Beijing strains with an intact region of difference (RD) 181, as well as strains presumably resembling ancestors of the whole Beijing genotype family, were mainly found in the Guangxi autonomous region.Conclusions/significanceThis is the largest M. tuberculosis VNTR-based genotyping study performed in China to date. The high percentage of Beijing isolates in the whole country and the presence in the South of strains representing early branching points may be an indication that the Beijing lineage originated from China, probably in the Guangxi region. Two modern lineages are shown here to represent the majority of non-Beijing Chinese isolates. The observed geographic distribution of the different lineages within China suggests that natural frontiers are major factors in their diffusion

Directory of Open Access Journals

PLoS ONE

Investigation on Mycobacterium tuberculosis diversity in China and the origin of the Beijing clade.

Hal-Diderot

Crossref

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Investigation on Mycobacterium tuberculosis Diversity in China and the Origin of the Beijing Clade

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