Boëlle, PY

Guillemot, D

Kardaś-Słoma, L

Temime, L

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Kardaś-Słoma L

Boëlle PY

Guillemot D

Temime L

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The relationship between the antibiotic consumption in hospitals and the community and the selection of methicillin-resistant <it>Staphylococcus aureus</it>

L Kardaś-Słoma

PY Boëlle

D Guillemot

L Temime

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The relationship between the antibiotic consumption in hospitals and the community and the selection of methicillin-resistant Staphylococcus aureus

Kardaś-Słoma, Lydia

Boëlle, Pierre-Yves

Guillemot, Didier

Temime, Laura

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HAL - Normandie Université

ORAL PRESENTATION Open Access
The relationship between the antibiotic
consumption in hospitals and the community
and the selection of methicillin-resistant
Staphylococcus aureus
L Kardaś-Słoma1,2,3*, PY Boëlle1,2, D Guillemot4, L Temime3
From International Conference on Prevention & Infection Control (ICPIC 2011)
Geneva, Switzerland. 29 June – 2 July 2011
Introduction / objectives
The impact of reductions in antibiotic use on the selec-
tion of antibiotic-resistant bacteria such as methicillin-
resistant Staphylococcus aureus (MRSA) is difficult to
assess, all the more so as they are often accompanied by
a concomitant increase in the use of a specific antibiotic
class.
Methods
We developed a computerized model of S. aureus trans-
mission in a hospital ward and in the community, where
methicillin-sensitive (MSSA), community-associated
MRSA (CA-MRSA) and hospital-associated MRSA (HA-
MRSA) strains co-circulate between these two settings.
We assessed the impact of a 15-50% reduction in anti-
biotic use in community and hospitals, under several
hypotheses regarding changes in the distribution of pre-
scribed antibiotics.
Results
An overall reduction in antibiotic use in the community
led to decreased frequency of MRSA but increased car-
riage of S. aureus in both hospital and community set-
tings. A similar reduction in hospitals had no impact on
community dynamics.
Antibiotic classes-specific changes over the time per-
iod of the reduction in global ambulatory antibiotic use
had an important impact on MRSA selection in hospi-
tals and in the community. For instance, in the hypoth-
esis of a 15% antibiotic use reduction, the induced
decrease in hospital MRSA frequency was 2.6 times less
important if this was accompanied by a concomitant
30% increase in the use of quinolones.
Conclusion
Antibiotic reduction policies may not prove sufficient to
decrease antibiotic-resistance frequency. They should
include a surveillance of changes in the consumption of
each antibiotic class.
Disclosure of interest
None declared.
Author details
1Pierre and Marie Curie University, Paris, France. 2Inserm, U 707, Paris, France.
3CNAM, Paris, France. 4Institut Pasteur,PhEMI, Paris, France.
Published: 29 June 2011
doi:10.1186/1753-6561-5-S6-O72
Cite this article as: Kardaś-Słoma et al.: The relationship between the
antibiotic consumption in hospitals and the community and the
selection of methicillin-resistant Staphylococcus aureus. BMC Proceedings
2011 5(Suppl 6):O72.
1Pierre and Marie Curie University, Paris, France
Full list of author information is available at the end of the article
Kardaś-Słoma et al. BMC Proceedings 2011, 5(Suppl 6):O72
http://www.biomedcentral.com/1753-6561/5/S6/O72
© 2011 Kardaś-Słoma et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.


http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3239488

The relationship between the antibiotic consumption in hospitals and the community and the selection of methicillin-resistant Staphylococcus aureus

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