Shigella is a gram-negative intracellular pathogen which causes bacillus diarrhea in humans. Besides clinical and gastrointestinal diseases, shigella causes food poisoning. In Iran, medicinal plants are used to treat infectious diseases. In this review article, the native medicinal plants to Iran that are effective on shigellosis were reported. For this purpose the key words Shigella, medicinal plants, essence, and extract were searched for in databases such as Scientific Information Database, Scopus, PubMed, Magiran, and Google Scholar and the related articles were retrieved and analyzed. Findings indicated that 18 medicinal plants native to Iran were effective on shigellosis, including Echinophora cinerea Boiss, Echinophora cinerea Boiss, Stachys lavandulifolia Vahl, Cuminum cyminum, Alliums stadium, Cymbopogon olivieri (Boiss), Salvia suffruticosa, Achillea wilhelmsii, Cleome iberica, Centaurea depressa, Teucrium polium L., Salvia mirzayanii, Haplophyllum canaliculatum, Geum coccineum, Mentha spicata L., Saliva aethiopis L., Salvia atropatana Bunge, Salvia oligophylla Auch. Ex Benth., Salvia macrosiphon Boiss. Identification of effective components of these plants could be a route to producing nature-based antibiotics for shigellosis
