Let kappa in N_+^l satisfy kappa_1 + *s + kappa_l = n, and let U_kappa denote the multislice of all strings u in [l]^n having exactly kappa_i coordinates equal to i, for all i in [l]. Consider the Markov chain on U_kappa where a step is a random transposition of two coordinates of u. We show that the log-Sobolev constant rho_kappa for the chain satisfies rho_kappa^{-1} <= n * sum_{i=1}^l 1/2 log_2(4n/kappa_i), which is sharp up to constants whenever l is constant. From this, we derive some consequences for small-set expansion and isoperimetry in the multislice, including a KKL Theorem, a Kruskal - Katona Theorem for the multislice, a Friedgut Junta Theorem, and a Nisan - Szegedy Theorem
