Every year trauma together with bone, joints and cartilage-associated diseases
usually involve structural damage, resulting in a severe pain and disability for millions of
people worldwide[1]. In regenerative medicine, cellular, tissue and organ-based approaches
are developed to restore biological functions that have been lost[2],[3]. Therefore, tissue
repair and regenerative medicine have attracted the interest of the scientific community,
providing promising results in preclinical models and clinical pilot studies.pre-print3341 K
