Background: F. hepatica infection is rare and mostly subclinical.
Migration of juvenile forms of F. hepatica into the host’s liver
is accompanied by an inflammatory reaction followed by fibrosis and
cirrhosis. Objective: The aim of this study was to evaluate oxidative
status by using a novel automated method in patients with Fasciola
hepatica. Methods: Twenty two patients with a diagnosis of F.
hepatica and 26 healthy volunteers were enrolled in the study. Their
Total antioxidant capacity status (TAC), total oxidant status (TOS) and
catalase were measured in them and oxidative stress index (OSI) was
calculated. These measurements were also taken for the control group
and the values were compared. Results: Plasma levels of total TOS and
OSI were significantly increased in patients as compared with healthy
controls (P<0.001, P<0.001, P=0.001, P=0.008) respectively. In
contrast, TAC level was significantly lower in patients as compared
with controls (p<0.05). There was no significant difference between
the catalase results of the two groups (p>0.05). Conclusion: Total
oxidative status and OSI were increased and total antioxidative status
capacity was decreased in patients with F. hepatica infeciton. A high
oxidative stress occurs during F. hepatica infection, which may cause
severe damage in both the liver