Katanasaka, Yasufumi

Kitamura, Yuka

Kodera, Yasuo

Koizumi, Fumiaki

Nishio, Kazuto

Tamura, Tomohide

Tsuda, Hitoshi

English

PubMed

Yasuo Kodera

Yasufumi Katanasaka

Yuka Kitamura

Hitoshi Tsuda

Kazuto Nishio

Tomohide Tamura

Fumiaki Koizumi

Springer - Publisher Connector

Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3

Achen MG: VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med

Alitalo K: Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. Faseb J

Alitalo K: Cardiovascular failure in mouse embryos deficient

Alitalo K: Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med

Alitalo K: Lymphangiogenesis and cancer metastasis. Nat Rev Cancer

Alitalo K: Lymphangiogenesis: molecular mechanisms and future promise. Cell

Alitalo K: Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol

Alitalo K: Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.

Alitalo K: The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res

Baruchel S: In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Neoplasia

Bielenberg DR: Potential therapeutic strategies for lymphatic metastasis. Microvasc Res

Cancer metastasis: building a framework. Cell

Christofori G: Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis. Mol Cancer Ther

Claesson-Welsh L: Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis.

Detmar M: Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med

ED: Tumor-induced activation of lymphatic endothelial cells via vascular endothelial growth factor receptor-2 is critical for prostate cancer lymphatic metastasis. Cancer Res

F: Antitumor activity of cetuximab against malignant glioma cells overexpressing EGFR deletion mutant variant III. Cancer Sci

Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity. Biochem Biophys Res Commun

Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages.

JW: Microenvironmental regulation of metastasis.

Kerbel RS: Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell

Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov

Multikinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res

Pathways targeting tumor lymphangiogenesis. Clin Cancer Res

Petrova TV: Lymphangiogenesis in development and human disease. Nature

Purchio T: Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection Kodera et al.

SA: Focus on lymphangiogenesis in tumor metastasis. Cancer Cell

SG: Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Mol Cancer Ther

SK: Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy. Clin Cancer Res

Skobe M: Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res

Skobe M: Molecular characterization of lymphatic endothelial cells.

Wu L: Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Res

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3218955

Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector