Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells

Angela Mohr; BB Tysnes; C Wild-Bode; CL Gladson; CP Geer; Daniel Habermehl; DP White; E Giannopoulou; H Sasaki; HS Friedman; JM Albert; Jürgen Debus; K Goetze; Katja Lindel; KD McCall-Culbreath; Klaus Weber; L Bello; Lena Wuerth; M Hartmann; M Wolff; MD Walker; ME Beckner; N Cordes; P Roca-Cusachs; PT Caswell; R Stupp; RH Goldbrunner; RJ Seitz; S Huang; S Monferran; SE Combs; SK Chintala; Stefan Rieken; Stephanie E Combs; SX Yang; T Ogata; TJ Manning Jr; V Senner; W Paulus; Y Fukushima

Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells

Authors: Angela Mohr
BB Tysnes
C Wild-Bode
CL Gladson
CP Geer
Daniel Habermehl
DP White
E Giannopoulou
H Sasaki
HS Friedman
JM Albert
Jürgen Debus
K Goetze
Katja Lindel
KD McCall-Culbreath
Klaus Weber
L Bello
Lena Wuerth
M Hartmann
M Wolff
MD Walker
ME Beckner
N Cordes
P Roca-Cusachs
PT Caswell
R Stupp
RH Goldbrunner
RJ Seitz
S Huang
S Monferran
SE Combs
SK Chintala
Stefan Rieken
Stephanie E Combs
SX Yang
T Ogata
TJ Manning Jr
V Senner
W Paulus
Y Fukushima
Publication date: 1 January 2011
Publisher: BioMed Central
Doi

Abstract

Sublethal photon irradiation was recently suspected to increase tumor cell motility and promote locoregional recurrence of disease. This study was set up to describe mechanisms underlying increased glioma cell migration through photon irradiation and to analyse the modifiability of photon-altered glioma cell motility by integrin inhibition