Brito, RG

Fernandes, TAP

Nascimento, CB

Saad-Magalhães, C

Sato, JO

English

PubMed

JO Sato

TAP Fernandes

CB Nascimento

RG Brito

C Saad-Magalhães

Springer - Publisher Connector

Inactive disease and remission rates after intraarticular steroids as initial therapy for juvenile idiopathic arhtritis (JIA)

POSTER PRESENTATION Open Access
Inactive disease and remission rates after
intraarticular steroids as initial therapy for
juvenile idiopathic arhtritis (JIA)
JO Sato*, TAP Fernandes, CB Nascimento, RG Brito, C Saad-Magalhães
From 18th Pediatric Rheumatology European Society (PReS) Congress
Bruges, Belgium. 14-18 September 2011
Objective
Describe rates of Inactive Disease (ID) and remission on
(CRM) and off medication (CR) after intraarticular ster-
oids (IAS) as initial therapy for JIA.
Methods
Frequency of ID, CRM and CR were calculated and esti-
mated by survival curves for all subjects with initial
treatment of IAS until additional therapy with DMARDs
or biologics was added.
Results
A review of 110 IAS sessions (246 treated joints) in 72
subjects was carried out. Median (IQR) follow-up dura-
tion was 4.3 years (2.7 – 6.1). JIA (ILAR) categories
were: persistent (55.6%) and extended oligoarthritis
(27.8%), enthesitis related arthritis (8.3%), undifferen-
tiated (6.9%) and psoriasic (1.4%). Knee (s) were treated
in 47.3%, both knees and ankles in 38.2%, and only
ankle (s) in 14.5%. Triamcinolone hexacetonide was
used in 86.1%. ID rates after the first IAS (n= 72) was
55.6%, at median (IQR) 2.4 months (1.1 – 6.6). After the
first IAS session, CRM and CR were observed in 25%
and 22.2%, respectively. After the second (n=22), ID,
CRM and CR occurred in 45.5%, 13.6% and 9.1%,
respectively, and after the third (n=12), 16.7%, 0% and
8.3%, respectively. Overall outcome was: CR in 23.6%,
CRM in 4.2%, 18.1% lost follow-up, 34.7% added
DMARD and 4.2% DMARD plus biologic. Median survi-
val for inactive disease, CRM and CR were 6.2, 11.5 and
21.6 months.
Conclusions
Inactive disease state occurred in about 50% and CR in
23.6% of patients. Effectiveness of IAS tends to
decreased with repeated injections, and this might be
considered to step up treatment.
Published: 14 September 2011
doi:10.1186/1546-0096-9-S1-P207
Cite this article as: Sato et al.: Inactive disease and remission rates after
intraarticular steroids as initial therapy for juvenile idiopathic arhtritis
(JIA). Pediatric Rheumatology 2011 9(Suppl 1):P207.
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* Correspondence: julianasato@fmb.unesp.br
Pediatric Rheumatology Unit, Botucatu Medical School, São Paulo State
University (UNESP), Brazil
Sato et al. Pediatric Rheumatology 2011, 9(Suppl 1):P207
http://www.ped-rheum.com/content/9/S1/P207
© 2011 Sato et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


Crossref

Pediatric Rheumatology

Brito RG

Nascimento CB

Fernandes TAP

Sato JO

Saad-Magalhães C

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Inactive disease and remission rates after intraarticular steroids as initial therapy for juvenile idiopathic arhtritis (JIA)

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