Czira, Maria E

Fornadi, Katalin

Kiss, Zoltan

Lazar, Alpar S.

Lindner, Anett

Molnar, Miklos Z

Mucsi, Istvan

Novak, Marta

Szentkiralyi, Andras

Toronyi, Eva

Zoller, Rezso

English

PubMed

Q Lai

F Melandro

G Spoletini

GB Levi Sandri

N Guglielmo

S Ginanni Corradini

PB Berloco

M Rossi

Crossref

BMC Geriatrics

Optimization of long-term graft survival after liver transplantation: the role of donor age

Asderakis, Argiris

Chaudhry, Aisha

Ilham, Mohamed Adel

Stephens, Michael

Phillips, Aled Owain

Online Research @ Cardiff

RO-101 Nitric oxide post-perfusion levels differ in DCD and DBD donor transplants [Abstract]

LAI, QUIRINO

MELANDRO, FABIO

SPOLETINI, GABRIELE

LEVI SANDRI, GIOVANNI BATTISTA

GUGLIELMO, NICOLA

GINANNI CORRADINI, Stefano

BERLOCO, Pasquale Bartolomeo

ROSSI, MASSIMO

Archivio della ricerca- Università di Roma La Sapienza

Springer - Publisher Connector

MEETING ABSTRACT Open Access
Optimization of long-term graft survival after liver
transplantation: the role of donor age
Q Lai*, F Melandro, G Spoletini, GB Levi Sandri, N Guglielmo, S Ginanni Corradini, PB Berloco, M Rossi
From XXIII Annual Meeting of the Italian Society of Geriatric Surgery
Lecce, Italy. 2-4 December 2010
Background
Nowadays, several solutions have been proposed for the
minimization of both organ shortage and prolonged
waiting times: the expansion of the donor pool using
aged donors represents a possible solution [1]. However,
it is not completely clear if the use of “extreme” donors
could cause unacceptable post-transplant adjunctive
risks [2]. Starting from these grounds, the aim of this
study is to evaluate the impact of donor age on long-
term graft survival.
Materials and methods
From January 2001 to April 2009, 188 consecutive liver
transplantations were performed at our Department.
The entire cohort was stratified in 4 subgroups accord-
ing to donor age: Group 1 (1st-2nd decade, n=34), Group
2 (3rd-4th decade, n=51), Group 3 (5th-6th decade, n=75)
and Group 4 (7th-8th decade, n=28). Donor, recipient
and transplantation characteristics were compared in
the 4 groups. ANOVA test and Kruskal-Wallis test were
used for the comparison of continuous and categorical
variables. Kaplan-Meier test was adopted for survival
analysis: log-rank test was used for comparison among
the groups’ survival rates.
Results
As expected, donor age, percentage of cerebrovascular
deaths, BMI and DRI resulted higher in the last group.
The male gender was prevalent in the 1st Group, while
macrovescicular steatosis resulted higher in the 3rd
Group. Recipient and immediate post-transplant features
resulted homogeneous among the groups. At survival
analysis, 5-year graft survival rates were progressively
worsened among the groups (82.4 vs 73.3 vs 64.7 vs
39.6%, respectively). At log-rank analysis, statistical sig-
nificance was observed between the first 2 Groups and
4th one (p-value 0.003 and 0.006, respectively), while a
boundary statistical significance was observed between
the 1st and 3rd Group. Figure 1.
Conclusions
In our experience, use of < 70 year-aged donors seems
to be safe, while very aged (over 70) donors give poor
long-term survival rates, despite similar initial post-
transplantation results. We could speculate that grafts
procured by very aged donors could be easier targets of
viral recurrence, late ischemia-reperfusion damage and
chronic rejection. A better allocation system for these
organs may be improved, preferring HCC recipients
who exceed transplant criteria to HCV ones [3].
* Correspondence: lai.quirino@libero.it
Department of General Surgery and Organ Transplantation, Sapienza
University, Rome, Italy
Figure 1 Graft survival in the 4 groups.
Lai et al. BMC Geriatrics 2011, 11(Suppl 1):A25
http://www.biomedcentral.com/1471-2318/11/S1/A25
© 2011 Lai et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Published: 24 August 2011
References
1. Pirenne J, Monbaliu D, Van Gelder F, Van Hees D, Aerts R, Verslype C, et al:
Liver transplantation using livers from septuagenarian and octogenarian
donors: an underused strategy to reduce mortality on the waiting list.
Transplant Proc 2005, 37:1180-1.
2. Tector AJ, Mangus RS, Chestovich P, Vianna R, Fridell JA, Milgrom ML, et al:
Use of extended criteria livers decreases wait time for liver
transplantation without adversely impacting posttransplant survival. Ann
Surg 2006, 244:439-50.
3. Sotiropoulos GC, Paul A, Molmenti E, Lang H, Frilling A, Napieralski BP, et al:
Liver transplantation for hepatocellular carcinoma in cirrhosis within the
Eurotransplant area: an additional option with “livers that nobody
wants”. Transpl 2005, 80:897-902.
doi:10.1186/1471-2318-11-S1-A25
Cite this article as: Lai et al.: Optimization of long-term graft survival
after liver transplantation: the role of donor age. BMC Geriatrics 2011 11
(Suppl 1):A25.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit
Lai et al. BMC Geriatrics 2011, 11(Suppl 1):A25
http://www.biomedcentral.com/1471-2318/11/S1/A25
Page 2 of 2


Berloco PB

Ginanni Corradini S

Guglielmo N

Levi Sandri GB

Spoletini G

Melandro F

Lai Q

Rossi M

Directory of Open Access Journals

Mownah, O A

Khurram, M A

Ray, C

Carter, Noel

Peaston, R

Phillipson, K

Gibbs, K

Gardener, K

Stamp, S

Dark, J H

Sunderland University Institutional Repository

Using Dialysis For Prolonged Ex Vivo Warm Reperfusion of DCD Hearts

et al: Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival. Ann Surg

Liver transplantation for hepatocellular carcinoma in cirrhosis within the Eurotransplant area: an additional option with “livers that nobody wants”. Transpl

Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance

http://doaj.org/search?source=%7B%22query%22%3A%7B%22bool%22%3A%7B%22must%22%3A%5B%7B%22term%22%3A%7B%22id%22%3A%2229ae6720100d4336a1bfa2ba0faedca3%22%7D%7D%5D%7D%7D%7D

Optimization of long-term graft survival after liver transplantation: the role of donor age

Abstract

Similar works

Full text

Available Versions

Crossref

Online Research @ Cardiff

Archivio della ricerca- Università di Roma La Sapienza

Springer - Publisher Connector

Directory of Open Access Journals

Sunderland University Institutional Repository

Springer - Publisher Connector