The paper is aimed to analyze the importance of water reuse within a strategy of integrated water resources management. Using an integrated systemic approach, the role of water in the set of relations which constitute a valuable source for the Mediterranean countries will be analyzed. The paper also aims to demonstrate how a correct management of water resources, have a positive impact on the socio-economic aspects of the area. At the Mediterranean regions the management of water appears to be complex, due to inhomogeneity of water availability. This should prompt to rethink the means of intervention in these countries, considering structural investments in order to ensure a fair exploitation of water resources