Fujimura, Masaki

Hori, Akihiro

Ohkura, Noriyuki

Tokuda, Akira

English

PubMed

Akihiro Hori

Masaki Fujimura

Noriyuki Ohkura

Akira Tokuda

Springer - Publisher Connector

Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs

Abstract
          
            Background
            Exhaled nitric oxide (ENO) is elevated in bronchial asthma patients, and inhaled corticosteroid therapy lowers the elevated ENO levels in such patients. ENO appears to be an inflammatory marker, but its role in the pathophysiology of cough remains unclear. This study aimed to elucidate the relationship between NO and increased cough reflex sensitivity induced by allergic airway reactions.
          
          
            Methods
            Cough reflex sensitivity to inhaled capsaicin was observed under NO depletion caused by NO synthase (NOS) inhibitors in non-sensitized and ovalbumin (OVA)-sensitized guinea pigs. The bronchoalveolar lavage fluid (BALF) was analyzed in an NO depletion setting using the inducible NOS (iNOS) inhibitor ONO1714 in OVA-sensitized guinea pigs.
          
          
            Results
            NO depletion by the non-selective NOS inhibitor L-NAME suppressed cough reflex sensitivity in non-sensitized guinea pigs and OVA-induced increase in cough reflex sensitivity in sensitized guinea pigs; however, iNOS inhibition caused by ONO1714 partially suppressed the OVA-induced increase in cough reflex sensitivity, but not the normal cough response in non-sensitized guinea pigs. ONO1714 did not change BAL cell components in OVA-sensitized guinea pigs.
          
          
            Conclusions
            The results suggest that NO may be involved not only in the normal cough reflex circuit, but also in the OVA-induced increase in cough reflex sensitivity, possibly via a different mechanism of action. Further studies are needed to clarify the precise mechanism.
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Crossref

Cough

An overview of the sensory receptors regulating cough. Cough

Anthes JC: TRPV1 antagonists as potential antitussive agents. Lung 2008, 186(Suppl 1):S59-S65.

Antigen inhalation unmasks NK-2 tachykinin receptor-mediated response in vagal afferents. Am J Respir Crit Care Med

Characterization of increased cough sensitivity after antigen challenge in guinea pigs. Clin Exp Allergy

Chung KF: Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung.

Cough receptor sensitivity and bronchial responsiveness in normal and asthmatic subjects. Eur Respir J

De Jongste JC: Exhaled nitric oxide measurements: clinical application and interpretation. Thorax

Eosinophilic tracheobronchitis and airway cough hypersensitivity in chronic non-productive cough. Clin Exp Allergy

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

IFLC: Neurokinins and inflammatory cell iNOS expression in guinea pigs with chronic allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol

Krombach F: Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury. Respiratory Research

Kung TT: Role of nitric oxide on eosinophilic lung inflammation in allergic mice.

Lodato RF: NG-Methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide.

N: A potent inhibitor of inducible nitric oxide synthase, ONO1714, a cyclic amide derivative. Biochem Biophys Res Commun

Nitric oxide and airway disease. Ann Med

Nitric oxide in health and disease of the respiratory system. Physiol Rev

NO or no NO in asthma? Thorax

O’Connor BJ: Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am J Respir Crit Care Med

Pavord ID: Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis. Eur Respir J

PJ: Increased nitric oxide in exhaled air of asthmatic patients. Lancet

PMA: Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax

Polak JM: Expression of inducible nitric oxide in human lung epithelial cells.

Polak JM: Induction of nitric oxide synthase in asthma. Lancet

RA: Endothelial nitric oxide synthase is expressed in cultured human bronchiolar epithelium.

RJ: A Method for the Standardized Offline Collection of Exhaled Nitric Oxide. Chest

Senent L: Airway inflammation and cough sensitivity in cough-variant asthma. Allergy

Shirato K: Induction of nitric oxide synthase by lipopolysaccharide inhalation enhances substance P-induced microvascular leakage in guinea-pigs. Eur Respir J

Stamler JS: A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds. Nature

Stamler JS: Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization.

T: iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response. Eur Respir J

Tiberio IFLC: Effect of nitric oxide synthases in chronic allergic airway inflammation and remodelling.

W: Nitric oxide synthase in guinea pig lower airway innervation. Neurosci Lett

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Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs

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