Introduction. Point prevalence surveys carried out in Europe in
2012 showed that Clostridium difficile is one of the most relevant
cause of Healthcare Associated Infection (HAIs). A region wide
prevalence survey confirmed a relevant frequency of Clostridium
difficile in Tuscany and in the University teaching hospital of
Pisa. The incidence of Clostridium difficile infection may belowered
by applying appropriate preventive measures. For this
purpose an electronic alert system has been activated in the
University Teaching Hospital of Pisa in March 2013. Aim of this
study is to define the incidence of CDAD after the implementation
of preventive measures. Methods. Data were collected
from the laboratory detection database and the notification of
clinical diagnosis. Incidence rates by ward, temporal trends of
incidence and notification rates of CDAD were calculated. Results.
The total incidence of CDAD was 4.95 cases per 10.000
patient days, with a great variability between different specialty
wards. The highest rates were scored in the gastroenterology,
infectious disease and paediatric oncohematology wards and
in the emergency department. Discussion. The incidence of
CDAD in the University teaching hospital of Pisa is higher than
the Italian average of 3,6 per 10.000 patient days but is comparable
to the European rates (4,1 per 10.000 patient days).
Conclusions. The electronic alert system is an important tool
for the timely implementation of control measures and the effectiveness
check of the measures applie