This paper summarizes the approach to safety for the LFR systems, developed on the basis of the recommendations of the Generation IV International Forum (GIF) Risk and Safety Working Group (RSWG) and taking into account the fundamental safety objectives and the Defence-in-Depth approach, as described by IAEA Safety Guides, as well as the Safety quantitative objectives reported in the European Utilities Requirements (EUR). LEADER project activities are focused on the resolution of the key issues as they emerged from the 6th FP ELSY project attempting to reach a new industrial size European Lead-cooled Fast Reactor (ELFR) configuration. Apart from the safety approach, the main results of the ELFR safety transient analysis, where the most important design basis condition (DBC) and design extension condition (DEC) transient initiators were re-analyzed using the system codes RELAP5 (ENEA), TRACE-FRED (PSI), SIM-LFR (KIT) and SIMMER (CIRTEN), are summarized
