APGAR scoring within 10’ after birth was assessed, heart rate, respiratory rate and body temperature were recorded in 11 donkey foals. The time needed to raise the head, observe suction reflex, acquire sternal recumbency, stand and acquire colostrum were recorded. Blood sample was collected before first feeding, a total CBC count, lactate and glucose concentration were evaluated. IgG status was also assessed at 24h. APGAR scoring was 7-8 and the head was raised immediately in 11/11; suckling reflex was acquired in 9,7’±4,7’, sternal recumbency within 3,7’±1,3’; standing up within 127,5’±70’; nursing the mare within 200’±67,4’. Blood lactate concentration mmol/L 2,08±0,5, blood glucose concentration mg/dl 93,7±24,5, WBC K/μL 5,9±1,5, neutrophils (N) K/μL 4,2±1,6, lymphocytes (L) K/μL 1,5±0,4, N:L 3,2±1,3. IgG was >800 mg/dl in 11/11 foals. Some of the semeiotic data, haematological and biochemical values showed some differences respect to equine foals