PLZF-expressing NKT cells establish residence at intravascular locations, failing to enter the circulation because of constitutive interactions with LFA-1 and ICAM-1

Abram

Adam K. Savage

Albert Bendelac

Andrew D. Luster

Auffray

Barral

Bartholomäus

Bendelac

Benlagha

Brigl

Darmoise

Doisne

Emoto

Fanyong Meng

Geissmann

Germanov

Godfrey

Gomez-Rodriguez

Griewank

Johnston

Kenneth A. Barr

Kinjo

Klaus G. Griewank

Kovalovsky

Matsuda

Mattner

McDonald

McNab

Michael G. Constantinides

Ohteki

Park

Pereira

Phillipson

Raberger

Savage

Seddon Y. Thomas

Semmling

Seth T. Scanlon

Shimaoka

Sriram

Stetson

Terashima

Thomas

Tupin

Winau

Wright

Zhou

English

PubMed

Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern and the mechanism of their intravascular behavior have not been elucidated. Using parabiotic mice, we demonstrated that, despite their intravascular location, most liver NKT cells failed to recirculate. Antibody blocking experiments established that they were retained locally through constitutive LFA-1–intercellular adhesion molecule (ICAM) 1 interactions. This unprecedented lifelong intravascular residence could be induced in conventional CD4 T cells by the sole expression of promyelocytic leukemia zinc finger (PLZF), a transcription factor specifically expressed in the NKT lineage. These findings reveal the unique genetic and biochemical pathway that underlies the innate intravascular surveillance program of NKT cells.</jats:p

Crossref

The Journal of Experimental Medicine

PLZF induces an intravascular surveillance program mediated by long-lived LFA-1–ICAM-1 interactions

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.

C57BL/6 Rag-c double-deficient (Rag2/ il2rg/) mice were obtained from Taconic. C57BL/6 J18/ mice were obtained from M. Taniguchi (Riken Research Center for Allergy and Immunology,

CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.

CD1d--GalCer tetramers were prepared as previously described (Benlagha

Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells.

Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.

Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells.

Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets.

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.

Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.

Going both ways: immune regulation via CD1d-dependent NKT cells.

Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade.

Lysosomal glycosphingolipid recognition by NKT cells.

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-/+ cells in the liver of mice.

Mice were anesthetized with 100 mg/kg ketamine and 10 mg/kg xylazine. A linear incision was made from the scapulae to

Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior.

Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway.

Natural killer T cells recognize diacylglycerol antigens from pathogenic

Origin of dendritic cells in peripheral lymphoid organs of mice.

Raising the NKT cell family.

Recognition of bacterial glycosphingolipids by natural killer T cells.

Recognition of lyso-phospholipids by human natural killer T lymphocytes.

The ins and outs of leukocyte integrin signaling.

The transcription factor PLZF directs the effector program of the NKT cell lineage.

The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells.

Unaltered phenotype, tissue distribution and function of Valpha14(+) NKT cells in germ-free mice.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3173247

PLZF induces an intravascular surveillance program mediated by long-lived LFA-1–ICAM-1 interactions

Abstract

Similar works

Full text

Available Versions

Crossref