A Benjamin

A Nick

AG Piggott

BS Nayak

BS Reddy

BV Beaver

D Prabu

EK Akkol

F Ahmad

GJ Kaur

GP Choudhary

How Yee Lai

HPS Makkar

HY Lai

JL Martindale

KA Myers

Kah Hwi Kim

L Braiman-Wiksman

M Maridass

MM Rane

MP Jorge

MU Sharief

P Aramwit

PC Molan

R Cooper

R Raina

TK Biswas

XB Fu

Yau Yan Lim

BMC Complementary and Alternative Medicine

English

PubMed

Springer - Publisher Connector

Potential dermal wound healing agent in Blechnum orientale Linn

Abstract
          
            Background
            
              Blechnum orientale Linn. (Blechnaceae) is used ethnomedicinally to treat wounds, boils, blisters or abscesses and sores, stomach pain and urinary bladder complaints. The aim of the study was to validate the ethnotherapeutic claim and to evaluate the effects of B. orientale water extract on wound healing activity.
          
          
            Methods
            Water extract of B. orientale was used. Excision wound healing activity was examined on Sprague-Dawley rats, dressed with 1% and 2% of the water extract. Control groups were dressed with the base cream (vehicle group, negative control) and 10% povidone-iodine (positive control) respectively. Healing was assessed based on contraction of wound size, mean epithelisation time, hydroxyproline content and histopathological examinations. Statistical analyses were performed using one way ANOVA followed by Tukey HSD test.
          
          
            Results
            Wound healing study revealed significant reduction in wound size and mean epithelisation time, and higher collagen synthesis in the 2% extract-treated group compared to the vehicle group. These findings were supported by histolopathological examinations of healed wound sections which showed greater tissue regeneration, more fibroblasts and angiogenesis in the 2% extract-treated group.
          
          
            Conclusions
            The ethnotherapeutic use of this fern is validated. The water extract of B. orientale is a potential candidate for the treatment of dermal wounds. Synergistic effects of both strong antioxidant and antibacterial activities in the extract are deduced to have accelerated the wound repair at the proliferative phase of the healing process.
          </jats:sec

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3170243

Potential dermal wound healing agent in Blechnum orientale Linn

Abstract

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