Background: Minor physical anomalies (MPAs) have been found to be more prevalent in schizophrenia than control participants in numerous studies and may index a potential endophenotype for schizophrenia.</p

A Lane

B Ismail

B Snitz

C Aksoy-Poyraz

Cohen

CT Gualtieri

D Gourion

E Cantor-Graae

EJ Joo

II Gottesman

JB Lohr

K Hata

K Yoshitsugu

Kenji Hashimoto

M Borenstein

MF Green

MF Waldrop

Michael T. Compton

MS Rosenberg

MT Compton

MW Lipsey

R Lal

R Rosenthal

Raymond C. K. Chan

RC Alexander

RCK Chan

RG Orwin

SL Collinson

SM Lawrie

SM Weinberg

ST Sivkov

TD Griffiths

Ting Xu

VH Akabaliev

PLoS ONE

English

PubMed

Minor physical anomalies (MPAs) have been found to be more prevalent in schizophrenia than control participants in numerous studies and may index a potential endophenotype for schizophrenia.To quantitatively define the magnitude of the difference in total MPA scores between patients with schizophrenia and healthy controls; to determine the degree of manifestation in unaffected first-degree relatives compared to patients and controls; and to investigate the degree of sensitivity among individual MPA items. and odds ratios) and corresponding confidence intervals were combined using the Comprehensive Meta-Analysis software package. = 0.32, 95% CI = −0.08, 0.73) between relatives and controls. The majority of MPAs items showed significant odds ratios (1.26–9.86) in comparing patients and controls.The findings indicate that medium effect size of MPAs have been demonstrated in patients with schizophrenia as compared to healthy controls, and to a lesser extent in unaffected relatives. These findings are consistent with the idea that MPAs may represent a putative endophenotype for schizophrenia. However, more research including first-degree family members is warranted

Xu Ting

Chan Raymond C. K.

Compton Michael T.

Public Library of Science (PLOS)

Minor Physical Anomalies in Patients with Schizophrenia, Unaffected First-Degree Relatives, and Healthy Controls: A Meta-Analysis

Xu, Ting

Chan, Raymond C. K.

Compton, Michael T.

Xu, T (reprint author), Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China.

Institutional Repository of Institute of Psychology, Chinese Academy of Sciences

Background: Minor physical anomalies (MPAs) have been found to be more prevalent in schizophrenia than control participants in numerous studies and may index a potential endophenotype for schizophrenia

Institute of Psychology,Chinese Academy Of Sciences

BACKGROUND: Minor physical anomalies (MPAs) have been found to be more prevalent in schizophrenia than control participants in numerous studies and may index a potential endophenotype for schizophrenia. AIM: To quantitatively define the magnitude of the difference in total MPA scores between patients with schizophrenia and healthy controls; to determine the degree of manifestation in unaffected first-degree relatives compared to patients and controls; and to investigate the degree of sensitivity among individual MPA items. METHODS: A systematic search was conducted on the literature pertaining to MPAs in patients with schizophrenia and unaffected relatives. Effect sizes (Cohen's d and odds ratios) and corresponding confidence intervals were combined using the Comprehensive Meta-Analysis software package. RESULTS: A large difference was found when examining 14 studies comprising 1207 patients with schizophrenia and 1007 healthy controls (d = 0.95, 95% CI = 0.63, 1.27). Six studies involving relatives of individuals with schizophrenia showed a medium effect size (d = 0.45, 95% CI = 0.29,0.62) between patients and relatives, but a small and non-significant effect size (d = 0.32, 95% CI = -0.08, 0.73) between relatives and controls. The majority of MPAs items showed significant odds ratios (1.26-9.86) in comparing patients and controls. CONCLUSIONS: The findings indicate that medium effect size of MPAs have been demonstrated in patients with schizophrenia as compared to healthy controls, and to a lesser extent in unaffected relatives. These findings are consistent with the idea that MPAs may represent a putative endophenotype for schizophrenia. However, more research including first-degree family members is warranted

Raymond C K Chan

Michael T Compton

Directory of Open Access Journals

Minor physical anomalies in patients with schizophrenia, unaffected first-degree relatives, and healthy controls: a meta-analysis.

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Minor Physical Anomalies in Patients with Schizophrenia, Unaffected First-Degree Relatives, and Healthy Controls: A Meta-Analysis

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Public Library of Science (PLOS)

Institutional Repository of Institute of Psychology, Chinese Academy of Sciences

Institute of Psychology,Chinese Academy Of Sciences

Directory of Open Access Journals

Public Library of Science (PLOS)

Crossref