We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of
microscopic colitis with presence of foamy macrophages.
A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin
and eosin-stained specimens collected from the large intestine, reviewed under ×200 or ×320 magnification.
No statistically significant improvement was found following the use of 5-amino-2-dihydroxybenzoic acid in therapy of the disease.
The use of Saccharomyces boulardii was associated with statistically significant improvement in clinical, endoscopic, and histopathological condition.
Use of magnesium caused a histological, statistically significant improvement but failed to have any effect on the clinical and endoscopic presentation.
In the group of children in whom no therapeutic intervention was provided, a statistically significant spontaneous clinical improvement was observed, but no
statistically significant changes in endoscopic and microscopic condition were found